Exosomes – Structure, Biogenesis and Biological Role in Non‐Small‐Cell Lung Cancer

• Published in: Scandinavian journal of immunology Vol. 81; no. 1; pp. 2 - 10
• Main Authors: Frydrychowicz, M., Kolecka‐Bednarczyk, A., Madejczyk, M., Yasar, S., Dworacki, G.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.01.2015
• Subjects: Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - pathology; Cell Communication; Endosomal Sorting Complexes Required for Transport - metabolism; Exosomes - chemistry; Exosomes - genetics; Exosomes - metabolism; Humans; Lipids - analysis; Lung cancer; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; MicroRNAs - genetics; Multivesicular Bodies - metabolism; Neovascularization, Pathologic - pathology; Tumor Microenvironment

Many different cells produce and release membraneous microvesicles (MV) or exosomes into their microenvironment. Exosomes represent a specific subtype of secreted derived vesicles which are defined as homogenous vesicles of 30–100 nm lined by a lipid bilayer, which contain a specific set of proteins...