Impact of P-glycoprotein on clopidogrel absorption - Taubert, Dirk; von Beckerath, Nicolas; Grimberg, Gundula; Lazar, Andreas; Jung, Norma; Goeser, Tobias; Kastrati, Adnan; Schömig, Albert; Schömig, Edgar (Clinical pharmacology and therapeutics, 2006)
Keywords: Administration, Oral; Area Under Curve; ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors; ATP-Binding Cassette, Sub-Family B, Member 1 - genetics; ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism; Biological Availability; Caco-2 Cells; Cell Membrane Permeability - drug effects; Coronary Artery Disease - genetics; Coronary Artery Disease - metabolism; Coronary Artery Disease - therapy; Dose-Response Relationship, Drug; Down-Regulation - drug effects; Down-Regulation - genetics; Gene Expression - drug effects; Genotype; Humans; Intestinal Absorption; Platelet Aggregation Inhibitors - administration & dosage; Platelet Aggregation Inhibitors - metabolism; Platelet Aggregation Inhibitors - pharmacokinetics; Polymorphism, Single Nucleotide - genetics; RNA, Messenger - genetics; RNA, Messenger - metabolism; Ticlopidine - administration & dosage; Ticlopidine - analogs & derivatives; Ticlopidine - metabolism; Ticlopidine - pharmacokinetics