Membrane and calcium clock mechanisms contribute variably as a function of temperature to setting cardiac pacemaker rate in zebrafish Danio rerio

• Published in: Journal of fish biology Vol. 95; no. 5; pp. 1265 - 1274
• Main Authors: Marchant, James L., Farrell, Anthony P.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.11.2019; Wiley Subscription Services, Inc
• Subjects: Acclimation; Acclimatization; Acclimatization - physiology; Animals; Calcium; Calcium - metabolism; Calcium Signaling; Channels; Danio rerio; EKG; Electrocardiography; fish; Freshwater fishes; HCN channels; Heart - physiology; heart failure; Heart Rate; Ion channels (cyclic nucleotide-gated); Membranes; Nucleotides; pacemaker; Ryanodine; Temperature; temperature acclimation; Thapsigargin; Zebrafish; Zebrafish - anatomy & histology; Zebrafish - physiology; heart rate; temperature acclimation; pacemaker; zebrafish; HCN channels; Danio rerio

Here, we show that heart rate in zebrafish Danio rerio is dependent upon two pacemaking mechanisms and it possesses a limited ability to reset the cardiac pacemaker with temperature acclimation. Electrocardiogram recordings, taken from individual, anaesthetised zebrafish that had been acclimated to...