Population pharmacokinetics of imipenem in critically ill patients with suspected ventilator‐associated pneumonia and evaluation of dosage regimens

• Published in: British journal of clinical pharmacology Vol. 78; no. 5; pp. 1022 - 1034
• Main Authors: Couffignal, Camille, Pajot, Olivier, Laouénan, Cédric, Burdet, Charles, Foucrier, Arnaud, Wolff, Michel, Armand‐Lefevre, Laurence, Mentré, France, Massias, Laurent
• Format: Journal Article
• Language: English
• Published: England Wiley 01.11.2014; BlackWell Publishing Ltd
• Subjects: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - blood; Anti-Bacterial Agents - pharmacokinetics; Anti-Bacterial Agents - therapeutic use; critical care; Critical Illness; Dose-Response Relationship, Drug; Female; Gram-Negative Bacteria - drug effects; Humans; imipenem; Imipenem - administration & dosage; Imipenem - blood; Imipenem - pharmacokinetics; Imipenem - therapeutic use; Infusions, Intravenous; Life Sciences; Male; Middle Aged; Models, Biological; Models, Statistical; Monte Carlo Method; Pharmaceutical sciences; Pharmacokinetics; Pneumonia, Ventilator-Associated - blood; Pneumonia, Ventilator-Associated - drug therapy; Pneumonia, Ventilator-Associated - metabolism; Pneumonia, Ventilator-Associated - microbiology; population pharmacokinetics; Prospective Studies; ventilator‐associated pneumonia; critical care; ventilator-associated pneumonia; imipenem; population pharmacokinetics; Population pharmacokinetics; Ventilator-associated pneumonia; criticalcare; Imipenem

Aims Significant alterations in the pharmacokinetics (PK) of antimicrobials have been reported in critically ill patients. We describe PK parameters of imipenem in intensive care unit (ICU) patients with suspected ventilator‐associated pneumonia and evaluate several dosage regimens. Methods This Fre...