Population pharmacokinetics of imipenem in critically ill patients with suspected ventilator‐associated pneumonia and evaluation of dosage regimens - Couffignal, Camille; Pajot, Olivier; Laouénan, Cédric; Burdet, Charles; Foucrier, Arnaud; Wolff, Michel; Armand‐Lefevre, Laurence; Mentré, France; Massias, Laurent (British journal of clinical pharmacology, 2014)
Keywords: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - blood; Anti-Bacterial Agents - pharmacokinetics; Anti-Bacterial Agents - therapeutic use; critical care; Critical Illness; Dose-Response Relationship, Drug; Female; Gram-Negative Bacteria - drug effects; Humans; imipenem; Imipenem - administration & dosage; Imipenem - blood; Imipenem - pharmacokinetics; Imipenem - therapeutic use; Infusions, Intravenous; Life Sciences; Male; Middle Aged; Models, Biological; Models, Statistical; Monte Carlo Method; Pharmaceutical sciences; Pharmacokinetics; Pneumonia, Ventilator-Associated - blood; Pneumonia, Ventilator-Associated - drug therapy; Pneumonia, Ventilator-Associated - metabolism; Pneumonia, Ventilator-Associated - microbiology; population pharmacokinetics; Prospective Studies; ventilator‐associated pneumonia; critical care; ventilator-associated pneumonia; imipenem; population pharmacokinetics; Population pharmacokinetics; Ventilator-associated pneumonia; criticalcare; Imipenem