Acute cross tolerance to midazolam, and not pentobarbital and pregnanolone, after a single dose of chlordiazepoxide in monkeys discriminating midazolam

• Published in: Behavioural pharmacology Vol. 19; no. 8; p. 796
• Main Authors: Gerak, Lisa R, McMahon, Lance R, France, Charles P
• Format: Journal Article
• Language: English
• Published: England 01.12.2008
• Subjects: Animals; Behavior, Animal; Chlordiazepoxide - administration & dosage; Chlordiazepoxide - pharmacology; Conditioning, Operant - drug effects; Discrimination Learning - drug effects; Discrimination Learning - physiology; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Female; GABA Modulators - administration & dosage; GABA Modulators - pharmacology; Macaca mulatta; Male; Midazolam - administration & dosage; Midazolam - pharmacology; Pentobarbital - administration & dosage; Pentobarbital - pharmacology; Time Factors

Although cross tolerance can develop among positive gamma-aminobutyric acidA (GABAA) modulators acting at the same modulatory site, cross tolerance does not always develop to drugs acting at sites that are different from the site of action of the drug administered chronically. To examine the relatio...