Moderate to vigorous physical activity volume is an important factor for managing nonalcoholic fatty liver disease: A retrospective study
Recently, the beneficial effects of increased physical activity (PA) on nonalcoholic fatty liver disease (NAFLD) in obese subjects were reported. However, the optimal strength and volume of PA in lifestyle modification to improve NAFLD pathophysiology and be recommended as an appropriate management...
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| Published in | Hepatology (Baltimore, Md.) Vol. 61; no. 4; pp. 1205 - 1215 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Wolters Kluwer Health, Inc
01.04.2015
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Recently, the beneficial effects of increased physical activity (PA) on nonalcoholic fatty liver disease (NAFLD) in obese subjects were reported. However, the optimal strength and volume of PA in lifestyle modification to improve NAFLD pathophysiology and be recommended as an appropriate management of this condition are unclear. The primary goal of this retrospective study was to estimate the beneficial effects of a varying volume of moderate to vigorous intensity PA (MVPA) on the improvement of NAFLD. A total of 169 obese, middle‐aged men were enrolled in a 12‐week weight reduction program through lifestyle modification consisting of dietary restrictions plus aerobic exercise. Among these obese subjects, 40 performed MVPA for <150 min·wk−1, 42 performed MVPA for 150‐250 min·wk−1, and 87 performed MVPA for >250 min·wk−1. The subjects in the MVPA ≥250 min·wk−1 group, in comparison with those in the MVPA <250 min·wk−1 group, showed significantly attenuated levels of hepatic steatosis (−31.8% versus −23.2%). This attenuation was likely independent of the detectable weight reduction. MVPA for ≥250 min·wk−1 in comparison with that for <150 min·wk−1 led to a significant decrease in the abdominal visceral adipose tissue severity (−40.6% versus −12.9%), levels of ferritin (−13.6% versus +1.5%), and lipid peroxidation (−15.1% versus −2.8%), and a significant increase in the adiponectin levels (+17.1% versus +5.6%). In association with these changes, the gene expression levels of sterol regulatory element‐binding protein‐1c and carnitine palmitoyltransferase‐1 in peripheral blood mononuclear cells also significantly decreased and increased, respectively. Conclusion: MVPA for ≥250 min·wk−1 as part of lifestyle management improves NAFLD pathophysiology in obese men. The benefits seem to be acquired through reducing inflammation and oxidative stress levels and altering fatty acid metabolism. (Hepatology 2015;61:1205–1215) |
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| AbstractList | Recently, the beneficial effects of increased physical activity (PA) on nonalcoholic fatty liver disease (NAFLD) in obese subjects were reported. However, the optimal strength and volume of PA in lifestyle modification to improve NAFLD pathophysiology and be recommended as an appropriate management of this condition are unclear. The primary goal of this retrospective study was to estimate the beneficial effects of a varying volume of moderate to vigorous intensity PA (MVPA) on the improvement of NAFLD. A total of 169 obese, middle-aged men were enrolled in a 12-week weight reduction program through lifestyle modification consisting of dietary restrictions plus aerobic exercise. Among these obese subjects, 40 performed MVPA for <150 min.wk super(-1), 42 performed MVPA for 150-250 min.wk super(-1), and 87 performed MVPA for >250 min.wk super(-1). The subjects in the MVPA greater than or equal to 250 min.wk super(-1) group, in comparison with those in the MVPA <250 min.wk super(-1) group, showed significantly attenuated levels of hepatic steatosis (-31.8% versus -23.2%). This attenuation was likely independent of the detectable weight reduction. MVPA for greater than or equal to 250 min.wk super(-1) in comparison with that for <150 min.wk super(-1) led to a significant decrease in the abdominal visceral adipose tissue severity (-40.6% versus -12.9%), levels of ferritin (-13.6% versus +1.5%), and lipid peroxidation (-15.1% versus -2.8%), and a significant increase in the adiponectin levels (+17.1% versus +5.6%). In association with these changes, the gene expression levels of sterol regulatory element-binding protein-1c and carnitine palmitoyltransferase-1 in peripheral blood mononuclear cells also significantly decreased and increased, respectively. Conclusion: MVPA for greater than or equal to 250 min.wk super(-1) as part of lifestyle management improves NAFLD pathophysiology in obese men. The benefits seem to be acquired through reducing inflammation and oxidative stress levels and altering fatty acid metabolism. (Hepatology 2015; 61:1205-1215) Recently, the beneficial effects of increased physical activity (PA) on nonalcoholic fatty liver disease (NAFLD) in obese subjects were reported. However, the optimal strength and volume of PA in lifestyle modification to improve NAFLD pathophysiology and be recommended as an appropriate management of this condition are unclear. The primary goal of this retrospective study was to estimate the beneficial effects of a varying volume of moderate to vigorous intensity PA (MVPA) on the improvement of NAFLD. A total of 169 obese, middle‐aged men were enrolled in a 12‐week weight reduction program through lifestyle modification consisting of dietary restrictions plus aerobic exercise. Among these obese subjects, 40 performed MVPA for <150 min·wk −1 , 42 performed MVPA for 150‐250 min·wk −1 , and 87 performed MVPA for >250 min·wk −1 . The subjects in the MVPA ≥250 min·wk −1 group, in comparison with those in the MVPA <250 min·wk −1 group, showed significantly attenuated levels of hepatic steatosis (−31.8% versus −23.2%). This attenuation was likely independent of the detectable weight reduction. MVPA for ≥250 min·wk −1 in comparison with that for <150 min·wk −1 led to a significant decrease in the abdominal visceral adipose tissue severity (−40.6% versus −12.9%), levels of ferritin (−13.6% versus +1.5%), and lipid peroxidation (−15.1% versus −2.8%), and a significant increase in the adiponectin levels (+17.1% versus +5.6%). In association with these changes, the gene expression levels of sterol regulatory element‐binding protein‐1c and carnitine palmitoyltransferase‐1 in peripheral blood mononuclear cells also significantly decreased and increased, respectively. Conclusion : MVPA for ≥250 min·wk −1 as part of lifestyle management improves NAFLD pathophysiology in obese men. The benefits seem to be acquired through reducing inflammation and oxidative stress levels and altering fatty acid metabolism. (H epatology 2015;61:1205–1215) Recently, the beneficial effects of increased physical activity (PA) on nonalcoholic fatty liver disease (NAFLD) in obese subjects were reported. However, the optimal strength and volume of PA in lifestyle modification to improve NAFLD pathophysiology and be recommended as an appropriate management of this condition are unclear. The primary goal of this retrospective study was to estimate the beneficial effects of a varying volume of moderate to vigorous intensity PA (MVPA) on the improvement of NAFLD. A total of 169 obese, middle-aged men were enrolled in a 12-week weight reduction program through lifestyle modification consisting of dietary restrictions plus aerobic exercise. Among these obese subjects, 40 performed MVPA for <150 min·wk(-1) , 42 performed MVPA for 150-250 min·wk(-1) , and 87 performed MVPA for >250 min·wk(-1) . The subjects in the MVPA ≥250 min·wk(-1) group, in comparison with those in the MVPA <250 min·wk(-1) group, showed significantly attenuated levels of hepatic steatosis (-31.8% versus -23.2%). This attenuation was likely independent of the detectable weight reduction. MVPA for ≥250 min·wk(-1) in comparison with that for <150 min·wk(-1) led to a significant decrease in the abdominal visceral adipose tissue severity (-40.6% versus -12.9%), levels of ferritin (-13.6% versus +1.5%), and lipid peroxidation (-15.1% versus -2.8%), and a significant increase in the adiponectin levels (+17.1% versus +5.6%). In association with these changes, the gene expression levels of sterol regulatory element-binding protein-1c and carnitine palmitoyltransferase-1 in peripheral blood mononuclear cells also significantly decreased and increased, respectively. MVPA for ≥250 min·wk(-1) as part of lifestyle management improves NAFLD pathophysiology in obese men. The benefits seem to be acquired through reducing inflammation and oxidative stress levels and altering fatty acid metabolism. Recently, the beneficial effects of increased physical activity (PA) on nonalcoholic fatty liver disease (NAFLD) in obese subjects were reported. However, the optimal strength and volume of PA in lifestyle modification to improve NAFLD pathophysiology and be recommended as an appropriate management of this condition are unclear. The primary goal of this retrospective study was to estimate the beneficial effects of a varying volume of moderate to vigorous intensity PA (MVPA) on the improvement of NAFLD. A total of 169 obese, middle‐aged men were enrolled in a 12‐week weight reduction program through lifestyle modification consisting of dietary restrictions plus aerobic exercise. Among these obese subjects, 40 performed MVPA for <150 min·wk−1, 42 performed MVPA for 150‐250 min·wk−1, and 87 performed MVPA for >250 min·wk−1. The subjects in the MVPA ≥250 min·wk−1 group, in comparison with those in the MVPA <250 min·wk−1 group, showed significantly attenuated levels of hepatic steatosis (−31.8% versus −23.2%). This attenuation was likely independent of the detectable weight reduction. MVPA for ≥250 min·wk−1 in comparison with that for <150 min·wk−1 led to a significant decrease in the abdominal visceral adipose tissue severity (−40.6% versus −12.9%), levels of ferritin (−13.6% versus +1.5%), and lipid peroxidation (−15.1% versus −2.8%), and a significant increase in the adiponectin levels (+17.1% versus +5.6%). In association with these changes, the gene expression levels of sterol regulatory element‐binding protein‐1c and carnitine palmitoyltransferase‐1 in peripheral blood mononuclear cells also significantly decreased and increased, respectively. Conclusion: MVPA for ≥250 min·wk−1 as part of lifestyle management improves NAFLD pathophysiology in obese men. The benefits seem to be acquired through reducing inflammation and oxidative stress levels and altering fatty acid metabolism. (Hepatology 2015;61:1205–1215) Recently, the beneficial effects of increased physical activity (PA) on nonalcoholic fatty liver disease (NAFLD) in obese subjects were reported. However, the optimal strength and volume of PA in lifestyle modification to improve NAFLD pathophysiology and be recommended as an appropriate management of this condition are unclear. The primary goal of this retrospective study was to estimate the beneficial effects of a varying volume of moderate to vigorous intensity PA (MVPA) on the improvement of NAFLD. A total of 169 obese, middle-aged men were enrolled in a 12-week weight reduction program through lifestyle modification consisting of dietary restrictions plus aerobic exercise. Among these obese subjects, 40 performed MVPA for <150 min·wk(-1) , 42 performed MVPA for 150-250 min·wk(-1) , and 87 performed MVPA for >250 min·wk(-1) . The subjects in the MVPA ≥250 min·wk(-1) group, in comparison with those in the MVPA <250 min·wk(-1) group, showed significantly attenuated levels of hepatic steatosis (-31.8% versus -23.2%). This attenuation was likely independent of the detectable weight reduction. MVPA for ≥250 min·wk(-1) in comparison with that for <150 min·wk(-1) led to a significant decrease in the abdominal visceral adipose tissue severity (-40.6% versus -12.9%), levels of ferritin (-13.6% versus +1.5%), and lipid peroxidation (-15.1% versus -2.8%), and a significant increase in the adiponectin levels (+17.1% versus +5.6%). In association with these changes, the gene expression levels of sterol regulatory element-binding protein-1c and carnitine palmitoyltransferase-1 in peripheral blood mononuclear cells also significantly decreased and increased, respectively.UNLABELLEDRecently, the beneficial effects of increased physical activity (PA) on nonalcoholic fatty liver disease (NAFLD) in obese subjects were reported. However, the optimal strength and volume of PA in lifestyle modification to improve NAFLD pathophysiology and be recommended as an appropriate management of this condition are unclear. The primary goal of this retrospective study was to estimate the beneficial effects of a varying volume of moderate to vigorous intensity PA (MVPA) on the improvement of NAFLD. A total of 169 obese, middle-aged men were enrolled in a 12-week weight reduction program through lifestyle modification consisting of dietary restrictions plus aerobic exercise. Among these obese subjects, 40 performed MVPA for <150 min·wk(-1) , 42 performed MVPA for 150-250 min·wk(-1) , and 87 performed MVPA for >250 min·wk(-1) . The subjects in the MVPA ≥250 min·wk(-1) group, in comparison with those in the MVPA <250 min·wk(-1) group, showed significantly attenuated levels of hepatic steatosis (-31.8% versus -23.2%). This attenuation was likely independent of the detectable weight reduction. MVPA for ≥250 min·wk(-1) in comparison with that for <150 min·wk(-1) led to a significant decrease in the abdominal visceral adipose tissue severity (-40.6% versus -12.9%), levels of ferritin (-13.6% versus +1.5%), and lipid peroxidation (-15.1% versus -2.8%), and a significant increase in the adiponectin levels (+17.1% versus +5.6%). In association with these changes, the gene expression levels of sterol regulatory element-binding protein-1c and carnitine palmitoyltransferase-1 in peripheral blood mononuclear cells also significantly decreased and increased, respectively.MVPA for ≥250 min·wk(-1) as part of lifestyle management improves NAFLD pathophysiology in obese men. The benefits seem to be acquired through reducing inflammation and oxidative stress levels and altering fatty acid metabolism.CONCLUSIONMVPA for ≥250 min·wk(-1) as part of lifestyle management improves NAFLD pathophysiology in obese men. The benefits seem to be acquired through reducing inflammation and oxidative stress levels and altering fatty acid metabolism. Recently, the beneficial effects of increased physical activity (PA) on nonalcoholic fatty liver disease (NAFLD) in obese subjects were reported. However, the optimal strength and volume of PA in lifestyle modification to improve NAFLD pathophysiology and be recommended as an appropriate management of this condition are unclear. The primary goal of this retrospective study was to estimate the beneficial effects of a varying volume of moderate to vigorous intensity PA (MVPA) on the improvement of NAFLD. A total of 169 obese, middle-aged men were enrolled in a 12-week weight reduction program through lifestyle modification consisting of dietary restrictions plus aerobic exercise. Among these obese subjects, 40 performed MVPA for <150 min·wk-1, 42 performed MVPA for 150-250 min·wk-1, and 87 performed MVPA for >250 min·wk-1. The subjects in the MVPA ≥250 min·wk-1 group, in comparison with those in the MVPA <250 min·wk-1 group, showed significantly attenuated levels of hepatic steatosis (-31.8% versus -23.2%). This attenuation was likely independent of the detectable weight reduction. MVPA for ≥250 min·wk-1 in comparison with that for <150 min·wk-1 led to a significant decrease in the abdominal visceral adipose tissue severity (-40.6% versus -12.9%), levels of ferritin (-13.6% versus +1.5%), and lipid peroxidation (-15.1% versus -2.8%), and a significant increase in the adiponectin levels (+17.1% versus +5.6%). In association with these changes, the gene expression levels of sterol regulatory element-binding protein-1c and carnitine palmitoyltransferase-1 in peripheral blood mononuclear cells also significantly decreased and increased, respectively. Conclusion: MVPA for ≥250 min·wk-1 as part of lifestyle management improves NAFLD pathophysiology in obese men. The benefits seem to be acquired through reducing inflammation and oxidative stress levels and altering fatty acid metabolism. (Hepatology 2015;61:1205-1215) |
| Author | Oh, Sechang Tanaka, Kiyoji Tsujimoto, Takehiko Shida, Takashi Yamagishi, Kazumasa Shoda, Junichi So, Rina |
| Author_xml | – sequence: 1 givenname: Sechang surname: Oh fullname: Oh, Sechang organization: University of Tsukuba – sequence: 2 givenname: Takashi surname: Shida fullname: Shida, Takashi organization: University of Tsukuba – sequence: 3 givenname: Kazumasa surname: Yamagishi fullname: Yamagishi, Kazumasa organization: University of Tsukuba – sequence: 4 givenname: Kiyoji surname: Tanaka fullname: Tanaka, Kiyoji organization: University of Tsukuba – sequence: 5 givenname: Rina surname: So fullname: So, Rina organization: University of Tsukuba – sequence: 6 givenname: Takehiko surname: Tsujimoto fullname: Tsujimoto, Takehiko organization: University of Tsukuba – sequence: 7 givenname: Junichi surname: Shoda fullname: Shoda, Junichi organization: University of Tsukuba |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25271091$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | 2014 by the American Association for the Study of Liver Diseases 2014 by the American Association for the Study of Liver Diseases. 2015 by the American Association for the Study of Liver Diseases |
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| Issue | 4 |
| Language | English |
| License | 2014 by the American Association for the Study of Liver Diseases. |
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| Notes | Supported in part by Grants‐in‐Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan (nos. 24390488,25282212, 25282172, 25293278, 26282191, 26293297, and 26670109). Sechang Oh and Rina So are International Research Fellows of the Japan Society for the Promotion of Science Potential conflict of interest: Nothing to report. See Editorial on Page 1115 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23 |
| PMID | 25271091 |
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| PublicationDate | April 2015 |
| PublicationDateYYYYMMDD | 2015-04-01 |
| PublicationDate_xml | – month: 04 year: 2015 text: April 2015 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Hoboken |
| PublicationTitle | Hepatology (Baltimore, Md.) |
| PublicationTitleAlternate | Hepatology |
| PublicationYear | 2015 |
| Publisher | Wolters Kluwer Health, Inc |
| Publisher_xml | – name: Wolters Kluwer Health, Inc |
| References | 1982; 14 1985; 28 2009; 41 2010; 36 2013; 45 2011; 60 2009 2008; 14 2006; 6 2012; 18 2004; 91 1995; 273 2007; 56 2012; 32 2011; 111 2013; 19 2010; 49 2006; 40 2011; 106 2009; 50 2013; 53 2008; 48 2011; 43 2008; 87 2003; 29 2005; 94 2012; 47 2012; 7 2010; 91 2007; 22 2007; 45 2014; 12 2010; 52 2009; 620 2006; 444 (hep27544-bib-0001-20241017) 2012; 47 (hep27544-bib-0016-20241017) 1995; 273 (hep27544-bib-0019-20241017) 1985; 28 (hep27544-bib-0021-20241017) 2010; 91 (hep27544-bib-0011-20241017) 2012; 18 (hep27544-bib-0018-20241017) 2010; 36 (hep27544-bib-0029-20241017) 2013; 53 (hep27544-bib-0032-20241017) 2013; 19 (hep27544-bib-0007-20241017) 2011; 60 (hep27544-bib-0027-20241017) 2010; 52 (hep27544-bib-0035-20241017) 2011; 43 (hep27544-bib-0004-20241017) 2011; 111 (hep27544-bib-0015-20241017) 2004; 91 (hep27544-bib-0024-20241017) 2008; 87 (hep27544-bib-0034-20241017) 2012; 32 (hep27544-bib-0008-20241017) 2009; 50 (hep27544-bib-0031-20241017) 2008; 14 (hep27544-bib-0006-20241017) 2009; 50 (hep27544-bib-0017-20241017) 2003; 29 (hep27544-bib-0023-20241017) 2006; 40 (hep27544-bib-0020-20241017) 2007; 45 (hep27544-bib-0002-20241017) 2006; 6 (hep27544-bib-0014-20241017) 1982; 14 (hep27544-bib-0028-20241017) 2010; 49 (hep27544-bib-0036-20241017) 2009; 41 (hep27544-bib-0022-20241017) 2006; 444 (hep27544-bib-0013-20241017) 2007; 22 (hep27544-bib-0030-20241017) 2009; 620 (hep27544-bib-0012-20241017) 2005; 94 (hep27544-bib-0009-20241017) 2013; 45 (hep27544-bib-0033-20241017) 2008; 48 (hep27544-bib-0003-20241017) 2007; 56 (hep27544-bib-0005-20241017) 2012; 7 (hep27544-bib-0026-20241017) 2011; 106 (hep27544-bib-0010-20241017) 2014; 12 25546322 - Hepatology. 2015 Apr;61(4):1115-7 |
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| SubjectTerms | Exercise Therapy - methods Gene expression Hepatology Humans Lifestyles Liver diseases Male Middle Aged Non-alcoholic Fatty Liver Disease - etiology Non-alcoholic Fatty Liver Disease - therapy Obesity - complications Obesity - therapy Retrospective Studies Weight control |
| Title | Moderate to vigorous physical activity volume is an important factor for managing nonalcoholic fatty liver disease: A retrospective study |
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