Reduced γ-Aminobutyric Acid and Glutamate+Glutamine Levels in Drug-Naïve Patients with First-Episode Schizophrenia but Not in Those at Ultrahigh Risk

• Published in: Neural plasticity Vol. 2016; no. 2016; pp. 1 - 9
• Main Authors: Lu, Zheng, Zhang, Jianye, Wang, Jijun, Li, Chunbo, Li, Gaiying, Zeng, Botao, Xu, Lihua, Cui, Huiru, Zhang, Tianhong, Tang, Yingying, Wang, Junjie, Liu, Hui, Li, Yu
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2016; John Wiley & Sons, Inc; Wiley
• Subjects: Adolescent; Adult; Alcohol; Brain; Drug abuse; Female; gamma-Aminobutyric Acid - metabolism; Glutamic Acid - metabolism; Glutamine - metabolism; Guardians; Humans; Informed consent; Magnetic Resonance Spectroscopy - methods; Male; Mental disorders; Pathophysiology; Patients; Prefrontal Cortex - metabolism; Prefrontal Cortex - physiopathology; Pregnancy; Proton Magnetic Resonance Spectroscopy - methods; Psychosis; Risk; Schizophrenia; Schizophrenia - metabolism; Spectrum analysis; Young Adult

Altered γ-aminobutyric acid (GABA), glutamate (Glu) levels, and an imbalance between GABAergic and glutamatergic neurotransmissions have been involved in the pathophysiology of schizophrenia. However, it remains unclear how these abnormalities impact the onset and course of psychosis. In the present...