Gut inflammation and dysbiosis in human motor neuron disease

• Published in: Physiological reports Vol. 5; no. 18; pp. e13443 - n/a
• Main Authors: Rowin, Julie, Xia, Yinglin, Jung, Barbara, Sun, Jun
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.09.2017; John Wiley and Sons Inc
• Subjects: Adult; Aged; Aged, 80 and over; ALS; Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - complications; Amyotrophic Lateral Sclerosis - microbiology; bacteria; Bacteroidetes; Bacteroidetes - isolation & purification; Case Report; Case Reports; Central nervous system; Digestive Conditions, Disorders and Treatments; Digestive system; Dysbacteriosis; dysbiosis; Dysbiosis - etiology; Dysbiosis - microbiology; Female; Firmicutes; Gastrointestinal Microbiome; Gastrointestinal Tract; Humans; Immunology; Inflammation; Inflammatory Bowel Diseases - etiology; Inflammatory Bowel Diseases - microbiology; Intestinal microflora; Intestine; Male; microbiome; Microbiomes; Middle Aged; Motor Control; motor neuron disease; Motor neuron diseases; Motor neurone disease; Neurodegenerative diseases; Neurological Conditions, Disorders and Treatments; Permeability; Rodents; Ruminococcaceae; Ruminococcus - isolation & purification; ALS; motor neuron disease; bacteria; inflammation; microbiome; dysbiosis

Amyotrophic lateral sclerosis (ALS) is a systemic disorder that involves dysfunction of multiple organs. Growing evidence has shown that neurodegenerative disorders with gut dysbiosis affect the central nervous system via pro‐inflammatory mediators thus impacting gut‐brain communications. We have de...