The Glu298Asp polymorphism of the NOS 3 gene as a determinant of the baseline production of nitric oxide

• Published in: Journal of hypertension Vol. 20; no. 10; p. 2023
• Main Authors: Veldman, Bart A, Spiering, Wilko, Doevendans, Peter A, Vervoort, Gerald, Kroon, Abraham A, de Leeuw, Peter W, Smits, Paul
• Format: Journal Article
• Language: English
• Published: England 01.10.2002
• Subjects: Adolescent; Adult; Alleles; Dipeptides - genetics; Dose-Response Relationship, Drug; Enzyme Inhibitors - administration & dosage; Female; Forearm - blood supply; Genotype; Humans; Infusions, Intra-Arterial; Male; Nitric Oxide - genetics; Nitric Oxide - metabolism; Nitric Oxide Synthase - drug effects; Nitric Oxide Synthase - genetics; Nitric Oxide Synthase Type III; Norepinephrine - administration & dosage; omega-N-Methylarginine - administration & dosage; Polymorphism, Genetic - genetics; Reference Values; Regional Blood Flow - drug effects; Regional Blood Flow - physiology; Vasoconstrictor Agents - administration & dosage

The endothelial nitric oxide synthase Glu298Asp polymorphism has been suggested to play a role in the development of hypertension, atherosclerosis and coronary artery disease. To investigate functional differences between the various genotypes with respect to basal nitric oxide (NO) production, we e...