Population Pharmacokinetic Analysis of Alirocumab in Healthy Volunteers or Hypercholesterolemic Subjects Using a Michaelis–Menten Approximation of a Target-Mediated Drug Disposition Model—Support for a Biologics License Application Submission: Part I - Martinez, Jean-Marie; Brunet, Aurélie; Hurbin, Fabrice; DiCioccio, A. Thomas; Rauch, Clémence; Fabre, David (Clinical pharmacokinetics, 2019)
Keywords: Adult; Aged; Antibodies, Monoclonal, Humanized - pharmacokinetics; Anticholesteremic Agents - pharmacokinetics; Biological Products - pharmacokinetics; Biological Variation, Individual; Cholesterol; Drug dosages; Female; Healthy Volunteers; Humans; Hypercholesterolemia - metabolism; Internal Medicine; Lipoproteins; Male; Medicine; Medicine & Public Health; Middle Aged; Models, Biological; Monoclonal antibodies; Multiple myeloma; Original; Original Research Article; Patients; Pharmacokinetics; Pharmacology/Toxicology; Pharmacotherapy; Statins; Studies