The etiology of rheumatoid arthritis

• Published in: Journal of autoimmunity Vol. 110; p. 102400
• Main Authors: Scherer, Hans Ulrich, Häupl, Thomas, Burmester, Gerd R.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2020
• Subjects: ACPA; AMPA; Etiology; Microbiome; Pathogenesis; Rheumatoid arthritis; Rheumatoid factor; Synovitis; Rheumatoid factor; Synovitis; AMPA; Etiology; Pathogenesis; Rheumatoid arthritis; ACPA; Microbiome

Rheumatoid arthritis is a heterogeneous disease, which can be, based on data combining genetic risk factors and autoantibodies, sub-classified into ACPA-positive and -negative RA. Presence of ACPA and RF as well as rising CRP-levels in some patients years before onset of clinical symptoms indicate t...