DNA methylation signatures of autoimmune diseases in human B lymphocytes

B lymphocytes play key roles in adaptive and innate immunity. In autoimmune diseases, their participation in disease instigation and/or progression has been demonstrated in both experimental models and clinical trials. Recent epigenetic investigations of human B lymphocyte subsets revealed the impor...

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Published in	Clinical immunology (Orlando, Fla.) Vol. 222; p. 108622
Main Author	Zouali, Moncef
Format	Journal Article
Language	English
Published	United States Elsevier Inc 01.01.2021
Subjects	Autoimmunity B lymphocyte Crohn's disease DNA methylation Inflammatory bowel disease Multiple sclerosis Rheumatoid arthritis Sjögren's syndrome Systemic lupus erythematosus Ulcerative colitis Autoimmunity RRMS MeCP2 Multiple sclerosis IBD TMPD SLE IFI44L UC DNMT Systemic lupus erythematosus CSF DNA methylation BLNK CD UV MS B lymphocyte IGF2 Crohn's disease 5mC PBMC AICDA RA Inflammatory bowel disease Sjögren's syndrome TSS Rheumatoid arthritis TCE IAP SAH SAM Ulcerative colitis ERK LT-a
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ISSN	1521-6616 1521-7035 1521-7035
DOI	10.1016/j.clim.2020.108622

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Abstract	B lymphocytes play key roles in adaptive and innate immunity. In autoimmune diseases, their participation in disease instigation and/or progression has been demonstrated in both experimental models and clinical trials. Recent epigenetic investigations of human B lymphocyte subsets revealed the importance of DNA methylation in exquisitely regulating the cellular activation and differentiation programs. This review discusses recent advances on the potential of DNA methylation to shape events that impart generation of plasma cells and memory B cells, providing novel insight into homeostatic regulation of the immune system. In parallel, epigenetic profiling of B cells from patients with systemic or organo-specific autoimmune diseases disclosed distinctive differential methylation regions that, in some cases, could stratify patients from controls. Development of tools for editing DNA methylation in the mammalian genome could be useful for future functional studies of epigenetic regulation by offering the possibility to edit locus-specific methylation, with potential translational applications. •B lymphocyte subsets exhibit distinctive DNA methylation patterns.•Dynamic differential DNA methylation underlies normal B cell differentiation.•DNA methylation limits B cell activation and differentiation.•Differentially methylated sites stratify autoimmune from control subjects.•Editing DNA methylation tools in the mammalian genome have potential translational applications.
AbstractList	B lymphocytes play key roles in adaptive and innate immunity. In autoimmune diseases, their participation in disease instigation and/or progression has been demonstrated in both experimental models and clinical trials. Recent epigenetic investigations of human B lymphocyte subsets revealed the importance of DNA methylation in exquisitely regulating the cellular activation and differentiation programs. This review discusses recent advances on the potential of DNA methylation to shape events that impart generation of plasma cells and memory B cells, providing novel insight into homeostatic regulation of the immune system. In parallel, epigenetic profiling of B cells from patients with systemic or organo-specific autoimmune diseases disclosed distinctive differential methylation regions that, in some cases, could stratify patients from controls. Development of tools for editing DNA methylation in the mammalian genome could be useful for future functional studies of epigenetic regulation by offering the possibility to edit locus-specific methylation, with potential translational applications.B lymphocytes play key roles in adaptive and innate immunity. In autoimmune diseases, their participation in disease instigation and/or progression has been demonstrated in both experimental models and clinical trials. Recent epigenetic investigations of human B lymphocyte subsets revealed the importance of DNA methylation in exquisitely regulating the cellular activation and differentiation programs. This review discusses recent advances on the potential of DNA methylation to shape events that impart generation of plasma cells and memory B cells, providing novel insight into homeostatic regulation of the immune system. In parallel, epigenetic profiling of B cells from patients with systemic or organo-specific autoimmune diseases disclosed distinctive differential methylation regions that, in some cases, could stratify patients from controls. Development of tools for editing DNA methylation in the mammalian genome could be useful for future functional studies of epigenetic regulation by offering the possibility to edit locus-specific methylation, with potential translational applications. B lymphocytes play key roles in adaptive and innate immunity. In autoimmune diseases, their participation in disease instigation and/or progression has been demonstrated in both experimental models and clinical trials. Recent epigenetic investigations of human B lymphocyte subsets revealed the importance of DNA methylation in exquisitely regulating the cellular activation and differentiation programs. This review discusses recent advances on the potential of DNA methylation to shape events that impart generation of plasma cells and memory B cells, providing novel insight into homeostatic regulation of the immune system. In parallel, epigenetic profiling of B cells from patients with systemic or organo-specific autoimmune diseases disclosed distinctive differential methylation regions that, in some cases, could stratify patients from controls. Development of tools for editing DNA methylation in the mammalian genome could be useful for future functional studies of epigenetic regulation by offering the possibility to edit locus-specific methylation, with potential translational applications. B lymphocytes play key roles in adaptive and innate immunity. In autoimmune diseases, their participation in disease instigation and/or progression has been demonstrated in both experimental models and clinical trials. Recent epigenetic investigations of human B lymphocyte subsets revealed the importance of DNA methylation in exquisitely regulating the cellular activation and differentiation programs. This review discusses recent advances on the potential of DNA methylation to shape events that impart generation of plasma cells and memory B cells, providing novel insight into homeostatic regulation of the immune system. In parallel, epigenetic profiling of B cells from patients with systemic or organo-specific autoimmune diseases disclosed distinctive differential methylation regions that, in some cases, could stratify patients from controls. Development of tools for editing DNA methylation in the mammalian genome could be useful for future functional studies of epigenetic regulation by offering the possibility to edit locus-specific methylation, with potential translational applications. •B lymphocyte subsets exhibit distinctive DNA methylation patterns.•Dynamic differential DNA methylation underlies normal B cell differentiation.•DNA methylation limits B cell activation and differentiation.•Differentially methylated sites stratify autoimmune from control subjects.•Editing DNA methylation tools in the mammalian genome have potential translational applications.
ArticleNumber	108622
Author	Zouali, Moncef
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Keywords	Autoimmunity RRMS MeCP2 Multiple sclerosis IBD TMPD SLE IFI44L UC DNMT Systemic lupus erythematosus CSF DNA methylation BLNK CD UV MS B lymphocyte IGF2 Crohn's disease 5mC PBMC AICDA RA Inflammatory bowel disease Sjögren's syndrome TSS Rheumatoid arthritis TCE IAP SAH SAM Ulcerative colitis ERK LT-a
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Snippet	B lymphocytes play key roles in adaptive and innate immunity. In autoimmune diseases, their participation in disease instigation and/or progression has been...
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SubjectTerms	Autoimmunity B lymphocyte Crohn's disease DNA methylation Inflammatory bowel disease Multiple sclerosis Rheumatoid arthritis Sjögren's syndrome Systemic lupus erythematosus Ulcerative colitis
Title	DNA methylation signatures of autoimmune diseases in human B lymphocytes
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