Increased calcium-independent phospholipase A2 activity in first but not in multiepisode chronic schizophrenia

• Published in: Biological psychiatry (1969) Vol. 57; no. 4; pp. 399 - 405
• Main Authors: Smesny, Stefan, Kinder, Daniel, Willhardt, Ingo, Rosburg, Timm, Lasch, Jürgen, Berger, Gregor, Sauer, Heinrich
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.02.2005; Elsevier Science
• Subjects: Adolescent; Adult; Adult and adolescent clinical studies; Age Factors; Analysis of Variance; Antipsychotic Agents - therapeutic use; Biological and medical sciences; Case-Control Studies; Chromatography, Thin Layer - methods; Chronic Disease; early psychosis; Female; first-episode schizophrenia; Fluorometry - methods; Group VI Phospholipases A2; Humans; iPLA2 activity; lipid metabolism; Male; Marijuana Smoking - blood; Medical sciences; Middle Aged; Phospholipases A - blood; Phospholipases A2; Psychiatric Status Rating Scales; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Schizophrenia; Schizophrenia - blood; Schizophrenia - drug therapy; Schizophrenia - enzymology; Schizophrenic Psychology; Sex Factors; Smoking - blood; Time Factors; iPLA2 activity; early psychosis; lipid metabolism; first-episode schizophrenia; Human; Chronicity; Healthy subject; Enzyme; Schizophrenia; Esterases; Phospholipase A; Carboxylic ester hydrolases; Psychosis; Hydrolases; Developmental stage; Psychopathology; Age; Comparative study

Increased activity of calcium independent phospholipase A2 (iPLA2) has repeatedly been found in the serum of unmedicated first-episode schizophrenia patients and assumed to reflect a pertubation of phospholipid metabolism. Previous studies in chronic schizophrenia were less conclusive. To explore wh...