Oxidative stress: a possible mechanism for lead-induced apoptosis and nephrotoxicity

• Published in: Toxicology mechanisms and methods Vol. 22; no. 9; pp. 705 - 710
• Main Authors: Jia, Qinghua, HA, Xiaoqin, Yang, Zhihua, Hui, Lin, Yang, Xiaopeng
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.11.2012; Taylor & Francis
• Subjects: Apoptosis; Apoptosis - drug effects; Cell Culture Techniques; Cell Survival - drug effects; Cells, Cultured; DNA Fragmentation - drug effects; Dose-Response Relationship, Drug; Flow Cytometry; human mesangial cells; Humans; Lead - toxicity; lead acetate; Mesangial Cells - drug effects; Mesangial Cells - metabolism; Mesangial Cells - pathology; Microscopy, Fluorescence; nephrotoxicity; Organometallic Compounds - toxicity; oxidative stress; Oxidative Stress - drug effects

Lead-induced nephrotoxicity is a human health hazard problem. In this study, Human mesangial cells (HMCs) were treated with different concentration of lead acetate (5, 10, 20 μmol/l) in order to investigate the oxidative stress and apoptotic changes. It was revealed that lead acetate could induce a...