Oxidative stress: a possible mechanism for lead-induced apoptosis and nephrotoxicity

Lead-induced nephrotoxicity is a human health hazard problem. In this study, Human mesangial cells (HMCs) were treated with different concentration of lead acetate (5, 10, 20 μmol/l) in order to investigate the oxidative stress and apoptotic changes. It was revealed that lead acetate could induce a...

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Published inToxicology mechanisms and methods Vol. 22; no. 9; pp. 705 - 710
Main Authors Jia, Qinghua, HA, Xiaoqin, Yang, Zhihua, Hui, Lin, Yang, Xiaopeng
Format Journal Article
LanguageEnglish
Published England Informa Healthcare 01.11.2012
Taylor & Francis
Subjects
Apoptosis
Apoptosis - drug effects
Cell Culture Techniques
Cell Survival - drug effects
Cells, Cultured
DNA Fragmentation - drug effects
Dose-Response Relationship, Drug
Flow Cytometry
human mesangial cells
Humans
Lead - toxicity
lead acetate
Mesangial Cells - drug effects
Mesangial Cells - metabolism
Mesangial Cells - pathology
Microscopy, Fluorescence
nephrotoxicity
Organometallic Compounds - toxicity
oxidative stress
Oxidative Stress - drug effects
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Abstract Lead-induced nephrotoxicity is a human health hazard problem. In this study, Human mesangial cells (HMCs) were treated with different concentration of lead acetate (5, 10, 20 μmol/l) in order to investigate the oxidative stress and apoptotic changes. It was revealed that lead acetate could induce a progressive loss in HMCs viability together with a significant increase in the number of apoptotic cells using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl tetrazolium (MTT) assay and flow cytometry, respectively. The apoptotic morphological changes induced by lead exposure in HMCs were demonstrated by PI-Hochest33342 staining. A DNA laddering pattern in lead-treated cells was shown, which could indicate nuclear fragmentation. In addition, lead acetate significantly increased the levels of malondialehyde (MDA) content and lactate dehydrogenase (LDH) activity. Therefore, it might be concluded that lead could promote HMCs' oxidative stress and apoptosis, which may be the chief mechanisms of lead-induced nephrotoxicity.
AbstractList Lead-induced nephrotoxicity is a human health hazard problem. In this study, Human mesangial cells (HMCs) were treated with different concentration of lead acetate (5, 10, 20 μmol/l) in order to investigate the oxidative stress and apoptotic changes. It was revealed that lead acetate could induce a progressive loss in HMCs viability together with a significant increase in the number of apoptotic cells using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl tetrazolium (MTT) assay and flow cytometry, respectively. The apoptotic morphological changes induced by lead exposure in HMCs were demonstrated by PI-Hochest33342 staining. A DNA laddering pattern in lead-treated cells was shown, which could indicate nuclear fragmentation. In addition, lead acetate significantly increased the levels of malondialehyde (MDA) content and lactate dehydrogenase (LDH) activity. Therefore, it might be concluded that lead could promote HMCs' oxidative stress and apoptosis, which may be the chief mechanisms of lead-induced nephrotoxicity.
Lead-induced nephrotoxicity is a human health hazard problem. In this study, Human mesangial cells (HMCs) were treated with different concentration of lead acetate (5, 10, 20 mu mol/l) in order to investigate the oxidative stress and apoptotic changes. It was revealed that lead acetate could induce a progressive loss in HMCs viability together with a significant increase in the number of apoptotic cells using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl tetrazolium (MTT) assay and flow cytometry, respectively. The apoptotic morphological changes induced by lead exposure in HMCs were demonstrated by PI-Hochest33342 staining. A DNA laddering pattern in lead-treated cells was shown, which could indicate nuclear fragmentation. In addition, lead acetate significantly increased the levels of malondialehyde (MDA) content and lactate dehydrogenase (LDH) activity. Therefore, it might be concluded that lead could promote HMCs' oxidative stress and apoptosis, which may be the chief mechanisms of lead-induced nephrotoxicity.
Author Yang, Xiaopeng
Jia, Qinghua
Yang, Zhihua
HA, Xiaoqin
Hui, Lin
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  organization: Experimental Center of Medicine, Lanzhou General Hospital of Lanzhou Military, People's Liberation Army, Key Laboratory of Stem Cells and Gene Drug of Gansu Province
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Snippet Lead-induced nephrotoxicity is a human health hazard problem. In this study, Human mesangial cells (HMCs) were treated with different concentration of lead...
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SubjectTerms Apoptosis
Apoptosis - drug effects
Cell Culture Techniques
Cell Survival - drug effects
Cells, Cultured
DNA Fragmentation - drug effects
Dose-Response Relationship, Drug
Flow Cytometry
human mesangial cells
Humans
Lead - toxicity
lead acetate
Mesangial Cells - drug effects
Mesangial Cells - metabolism
Mesangial Cells - pathology
Microscopy, Fluorescence
nephrotoxicity
Organometallic Compounds - toxicity
oxidative stress
Oxidative Stress - drug effects
Title Oxidative stress: a possible mechanism for lead-induced apoptosis and nephrotoxicity
URI https://www.tandfonline.com/doi/abs/10.3109/15376516.2012.718811
https://www.ncbi.nlm.nih.gov/pubmed/22894711
https://search.proquest.com/docview/1560130690
Volume 22
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