Reinforcing effects of synthetic cathinones in rhesus monkeys: Dose-response and behavioral economic analyses

• Published in: Pharmacology, biochemistry and behavior Vol. 202; p. 173112
• Main Authors: de Moura, Fernando B., Sherwood, Alexander, Prisinzano, Thomas E., Paronis, Carol A., Bergman, Jack, Kohut, Stephen J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2021
• Subjects: Alkaloids - administration & dosage; Alkaloids - metabolism; Animals; Behavior, Animal - drug effects; Behavioral economics; Benzodioxoles - administration & dosage; Benzodioxoles - metabolism; Cathinone; Central Nervous System Stimulants - administration & dosage; Central Nervous System Stimulants - metabolism; Cocaine - administration & dosage; Dopamine Plasma Membrane Transport Proteins - metabolism; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Methamphetamine - administration & dosage; Methamphetamine - analogs & derivatives; Methamphetamine - metabolism; N-Methyl-3,4-methylenedioxyamphetamine - administration & dosage; N-Methyl-3,4-methylenedioxyamphetamine - metabolism; Pentanones - administration & dosage; Protein Binding; Pyrrolidines - administration & dosage; Pyrrolidines - metabolism; Reinforcement, Psychology; Rhesus monkeys; Self Administration; Serotonin Plasma Membrane Transport Proteins - metabolism; Synthetic Drugs - administration & dosage; Synthetic Drugs - metabolism; Self-administration; Behavioral economics; Cathinone; Rhesus monkeys

The abuse of synthetic cathinones (“bath salts”) with psychomotor stimulant and/or entactogenic properties emerged as a public health concern when they were introduced as “legal” alternatives to drugs of abuse such as cocaine or MDMA. In this study, experiments were conducted in nonhuman primates to...