Cerebral atrophy in Parkinson’s disease with and without dementia: a comparison with Alzheimer’s disease, dementia with Lewy bodies and controls

• Published in: Brain (London, England : 1878) Vol. 127; no. 4; pp. 791 - 800
• Main Authors: Burton, Emma J., McKeith, Ian G., Burn, David J., Williams, E. David, O’Brien, John T.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.04.2004; Oxford Publishing Limited (England)
• Subjects: Aged; Alzheimer Disease - pathology; atrophy; BA = Brodmann area; Biological and medical sciences; Brain - pathology; CAMCOG = Cambridge Cognitive Examination; Cross-Sectional Studies; Dementia; Dementia - etiology; Dementia - pathology; DLB = dementia with Lewy bodies; Female; FWHM = full width at half maximum; Humans; Lewy Body Disease - pathology; Magnetic Resonance Imaging - methods; Male; Medical sciences; MMSE = Mini‐Mental State Examination; MNI = Montreal Neurological Institute; MRI; Neurology; Parkinson Disease - complications; Parkinson Disease - pathology; Parkinson’s disease; PDD = Parkinson’s disease with dementia; ROI = region of interest; SPM = statistical parametric mapping; TIV = total intracranial volume; UPDRS III = Unified Parkinson’s Disease Rating Scale III; VaD = vascular dementia; VBM = voxel‐based morphometry; voxel‐based morphometry; Cerebral cortex; Nervous system diseases; Parkinson's disease; Alzheimer disease; Lewy body disease; MRI; Central nervous system; Parkinson disease; voxel-based morphometry; Nuclear magnetic resonance imaging; Cerebral disorder; Atrophy; Voxel; Central nervous system disease; Lewy body dementia; Medical imagery; dementia; Degenerative disease; Morphometry; Comparative study; Extrapyramidal syndrome

Parkinson’s disease is a common neurodegenerative disorder primarily characterized by rigidity, tremor and bradykinesia. Cognitive impairment and neuropsychiatric symptoms are frequent in Parkinson’s disease, with a 70% cumulative incidence of dementia. The aim of this cross‐sectional study was to e...