The pathways to tumor suppression via route p38

• Published in: Trends in biochemical sciences (Amsterdam. Regular ed.) Vol. 32; no. 8; pp. 364 - 371
• Main Authors: Han, Jiahuai, Sun, Peiqing
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2007
• Subjects: Animals; Cell Cycle; Cell Proliferation; Cellular Senescence; DNA Damage; Gene Deletion; Humans; Inflammation; Models, Biological; Neoplasm Metastasis; Neoplasms - metabolism; Neovascularization, Pathologic; Oncogenes; p38 Mitogen-Activated Protein Kinases - metabolism; ras Proteins - metabolism

Besides its well-known functions in inflammation and other stresses, the p38 mitogen-activated protein kinase pathway also negatively regulates cell proliferation and tumorigenesis. Inactivation of the p38 pathway enhances cellular transformation and renders mice prone to tumor development with conc...