Fluorine-19 NMR of integral membrane proteins illustrated with studies of GPCRs

• Published in: Current opinion in structural biology Vol. 23; no. 5; pp. 740 - 747
• Main Authors: Didenko, Tatiana, Liu, Jeffrey J, Horst, Reto, Stevens, Raymond C, Wüthrich, Kurt
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2013
• Subjects: Fluorine Radioisotopes; Membrane Proteins - chemistry; Membrane Proteins - metabolism; Nuclear Magnetic Resonance, Biomolecular - methods; Receptors, G-Protein-Coupled - chemistry; Receptors, G-Protein-Coupled - metabolism

•Renewed interest in 19F NMR for structural biology of complex molecular systems.•Advances in biochemistry and NMR techniques enable 19F NMR studies of new classes of membrane proteins.•19F NMR of GPCRs complements crystal structures with data on protein dynamics in long-range signal transfer. Fluor...