Fluorine-19 NMR of integral membrane proteins illustrated with studies of GPCRs
•Renewed interest in 19F NMR for structural biology of complex molecular systems.•Advances in biochemistry and NMR techniques enable 19F NMR studies of new classes of membrane proteins.•19F NMR of GPCRs complements crystal structures with data on protein dynamics in long-range signal transfer. Fluor...
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| Published in | Current opinion in structural biology Vol. 23; no. 5; pp. 740 - 747 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.10.2013
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| Subjects | |
| Online Access | Get full text |
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| Abstract | •Renewed interest in 19F NMR for structural biology of complex molecular systems.•Advances in biochemistry and NMR techniques enable 19F NMR studies of new classes of membrane proteins.•19F NMR of GPCRs complements crystal structures with data on protein dynamics in long-range signal transfer.
Fluorine-19 is a spin-½ NMR isotope with high sensitivity and large chemical shift dispersion, which makes it attractive for high resolution NMR spectroscopy in solution. For studies of membrane proteins it is further of interest that 19F is rarely found in biological materials, which enables observation of extrinsic 19F labels with minimal interference from background signals. Today, after a period with rather limited use of 19F NMR in structural biology, we witness renewed interest in this technology for studies of complex supramolecular systems. Here we report on recent 19F NMR studies with the G protein-coupled receptor family of membrane proteins. |
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| AbstractList | Fluorine-19 is a spin-½ NMR isotope with high sensitivity and large chemical shift dispersion, which makes it attractive for high resolution NMR spectroscopy in solution. For studies of membrane proteins it is further of interest that
19
F is rarely found in biological materials, which enables observation of extrinsic
19
F labels with minimal interference from background signals. Today, after a period with rather limited use of
19
F-NMR in structural biology, we witness renewed interest in this technology for studies of complex supramolecular systems. Here we report on recent
19
F-NMR studies with the G-protein-coupled receptor family of membrane proteins. Fluorine-19 is a spin-½ NMR isotope with high sensitivity and large chemical shift dispersion, which makes it attractive for high resolution NMR spectroscopy in solution. For studies of membrane proteins it is further of interest that (19)F is rarely found in biological materials, which enables observation of extrinsic (19)F labels with minimal interference from background signals. Today, after a period with rather limited use of (19)F NMR in structural biology, we witness renewed interest in this technology for studies of complex supramolecular systems. Here we report on recent (19)F NMR studies with the G protein-coupled receptor family of membrane proteins. •Renewed interest in 19F NMR for structural biology of complex molecular systems.•Advances in biochemistry and NMR techniques enable 19F NMR studies of new classes of membrane proteins.•19F NMR of GPCRs complements crystal structures with data on protein dynamics in long-range signal transfer. Fluorine-19 is a spin-½ NMR isotope with high sensitivity and large chemical shift dispersion, which makes it attractive for high resolution NMR spectroscopy in solution. For studies of membrane proteins it is further of interest that 19F is rarely found in biological materials, which enables observation of extrinsic 19F labels with minimal interference from background signals. Today, after a period with rather limited use of 19F NMR in structural biology, we witness renewed interest in this technology for studies of complex supramolecular systems. Here we report on recent 19F NMR studies with the G protein-coupled receptor family of membrane proteins. |
| Author | Liu, Jeffrey J Didenko, Tatiana Horst, Reto Stevens, Raymond C Wüthrich, Kurt |
| AuthorAffiliation | 1 Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA 2 Skaggs Institute of Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA |
| AuthorAffiliation_xml | – name: 2 Skaggs Institute of Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA – name: 1 Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA |
| Author_xml | – sequence: 1 givenname: Tatiana surname: Didenko fullname: Didenko, Tatiana organization: Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA – sequence: 2 givenname: Jeffrey J surname: Liu fullname: Liu, Jeffrey J organization: Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA – sequence: 3 givenname: Reto surname: Horst fullname: Horst, Reto organization: Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA – sequence: 4 givenname: Raymond C surname: Stevens fullname: Stevens, Raymond C organization: Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA – sequence: 5 givenname: Kurt surname: Wüthrich fullname: Wüthrich, Kurt email: wuthrich@scripps.edu organization: Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA |
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| Snippet | •Renewed interest in 19F NMR for structural biology of complex molecular systems.•Advances in biochemistry and NMR techniques enable 19F NMR studies of new... Fluorine-19 is a spin-½ NMR isotope with high sensitivity and large chemical shift dispersion, which makes it attractive for high resolution NMR spectroscopy... |
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| SubjectTerms | Fluorine Radioisotopes Membrane Proteins - chemistry Membrane Proteins - metabolism Nuclear Magnetic Resonance, Biomolecular - methods Receptors, G-Protein-Coupled - chemistry Receptors, G-Protein-Coupled - metabolism |
| Title | Fluorine-19 NMR of integral membrane proteins illustrated with studies of GPCRs |
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