Hypoalbuminemia affects the spatio-temporal tissue distribution of ochratoxin A in liver and kidneys: consequences for organ toxicity

• Published in: Archives of toxicology Vol. 96; no. 11; pp. 2967 - 2981
• Main Authors: Hassan, Reham, Friebel, Adrian, Brackhagen, Lisa, Hobloss, Zaynab, Myllys, Maiju, González, Daniela, Albrecht, Wiebke, Mohammed, Elsayed S. I., Seddek, Abdel-latif, Marchan, Rosemarie, Cadenas, Cristina, Cramer, Benedikt, Humpf, Hans-Ulrich, Hartl, Lukas, Simbrunner, Benedikt, Reiberger, Thomas, Trauner, Michael, Hoehme, Stefan, Degen, Gisela H., Hengstler, Jan G., Ghallab, Ahmed
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2022; Springer Nature B.V
• Subjects: Albumin; Archives & records; Bile ducts; Binding; Biomedical and Life Sciences; Biomedicine; Blood vessels; Breast cancer; Capillaries; Environmental Health; Epithelial cells; Epithelium; Filtration; Fluorescence; Gastroenterology; Hepatocytes; Hepatology; Hepatotoxicity; Inflammatory diseases; Internal medicine; Kidneys; Liver; Liver diseases; Mycotoxins; Occupational Medicine/Industrial Medicine; Ochratoxin A; Pharmacokinetics; Pharmacology/Toxicology; Plasma; Proteins; Serum albumin; Substrates; Tissues; Toxicity; Toxicokinetics and Metabolism; Toxicology; Veterinary medicine; Albumin binding; Toxicokinetics; Intravital imaging; Pharmacokinetics; Mycotoxins

Hypoalbuminemia (HA) is frequently observed in systemic inflammatory diseases and in liver disease. However, the influence of HA on the pharmacokinetics and toxicity of compounds with high plasma albumin binding remained insufficiently studied. The ‘ lack-of-delivery-concept ’ postulates that HA lea...