Oral glucose ingestion attenuates exercise-induced activation of 5′-AMP-activated protein kinase in human skeletal muscle

• Published in: Biochemical and biophysical research communications Vol. 342; no. 3; pp. 949 - 955
• Main Authors: Akerstrom, Thorbjorn C.A., Birk, Jesper B., Klein, Ditte K., Erikstrup, Christian, Plomgaard, Peter, Pedersen, Bente Klarlund, Wojtaszewski, Jørgen F.P.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 14.04.2006
• Subjects: Administration, Oral; Adult; AMP-Activated Protein Kinases; AMPK; Enzyme Activation - drug effects; Exercise; Exercise - physiology; Glucose; Glucose - administration & dosage; Glucose - pharmacology; Glycogen - metabolism; Humans; Male; Multienzyme Complexes - metabolism; Muscle, Skeletal - drug effects; Muscle, Skeletal - enzymology; Phosphorylation; Protein-Serine-Threonine Kinases - metabolism; Quadriceps Muscle - metabolism; Skeletal muscle; Time Factors; AMPK; Exercise; Glucose; Skeletal muscle

5′-AMP-activated protein kinase (AMPK) has been suggested to be a ‘metabolic master switch’ regulating various aspects of muscle glucose and fat metabolism. In isolated rat skeletal muscle, glucose suppresses the activity of AMPK and in human muscle glycogen loading decreases exercise-induced AMPK a...