IgG to Galactose-Alpha-1,3-Galactose: Impact of Alpha-Gal IgE Sensitization, Blood Type, and Tick Bites

• Published in: Antibodies (Basel) Vol. 14; no. 2; p. 43
• Main Authors: Ailsworth, Samuel M., MacCallum, Matthew, Richards, Nathan E., Workman, Lisa J., Schoppee Bortz, Pamela, Makin, Thomas, Platts-Mills, Thomas A. E., Wilson, Jeffrey M.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 16.05.2025
• Subjects: Adults; Allergies; alpha-gal; Antibodies; Arachnids; Bites and stings; Blood; Blood groups; Carbohydrates; Comparative analysis; COVID-19 vaccines; Demographics; Demography; Diet; Galactose; Health aspects; IgE; IgG; Immunoglobulin E; Immunoglobulin G; Immunoglobulin M; Insect bites; Isotypes; Mammals; Measurement; Meat; Medical personnel; Patients; Physiological aspects; Population studies; Questionnaires; red meat allergy; Review boards; Statistical analysis; Testing; Ticks; Vaccines; Xenotransplantation; United States; United States > US; Virginia; IgG; alpha-gal; ticks; IgE; red meat allergy

Background: Antibodies to galactose-alpha-1,3-galactose (alpha-gal), particularly the IgM and IgG isotypes, are abundant in human sera. These antibodies are known to be an important xenotransplantation barrier, but the full implications of these antibodies to health and disease remain incompletely u...