Mechanical stretch inhibits myoblast-to-adipocyte differentiation through Wnt signaling
Myoblasts are able to differentiate into other mesenchymal lineages including adipocytes and osteoblasts. However, it is not known how this differentiation is normally regulated in intact animals and humans. Here, we subjected cultured C2C12 myoblasts to cyclic mechanical stretch (20% elongation) du...
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| Published in | Biochemical and biophysical research communications Vol. 329; no. 1; pp. 381 - 385 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
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United States
Elsevier Inc
01.04.2005
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| Abstract | Myoblasts are able to differentiate into other mesenchymal lineages including adipocytes and osteoblasts. However, it is not known how this differentiation is normally regulated in intact animals and humans. Here, we subjected cultured C2C12 myoblasts to cyclic mechanical stretch (20% elongation) during differentiation into adipocytes. Mechanical stretch inhibited the myoblast-to-adipocyte differentiation significantly, concurrent with an enhanced expression of Wnt10b mRNA. Inhibition of the Wnt signaling by incubation of the myoblasts with a soluble Wnt ligand, sFRP-2, abolished the inhibitory function of mechanical stretch on adipogenesis. These findings provide evidence that mechanical stretch inhibits myoblast-to-adipocyte differentiation possibly through Wnt signaling. |
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| AbstractList | Myoblasts are able to differentiate into other mesenchymal lineages including adipocytes and osteoblasts. However, it is not known how this differentiation is normally regulated in intact animals and humans. Here, we subjected cultured C2C12 myoblasts to cyclic mechanical stretch (20% elongation) during differentiation into adipocytes. Mechanical stretch inhibited the myoblast-to-adipocyte differentiation significantly, concurrent with an enhanced expression of Wnt10b mRNA. Inhibition of the Wnt signaling by incubation of the myoblasts with a soluble Wnt ligand, sFRP-2, abolished the inhibitory function of mechanical stretch on adipogenesis. These findings provide evidence that mechanical stretch inhibits myoblast-to-adipocyte differentiation possibly through Wnt signaling. |
| Author | Akaogi, Hiroshi Tsuchiya, Kohei Williams, R. Sanders Miyaki, Shigeru Tateishi, Tetsuya Ushida, Takashi Akimoto, Takayuki Yan, Zhen |
| Author_xml | – sequence: 1 givenname: Takayuki surname: Akimoto fullname: Akimoto, Takayuki email: takayuki.akimoto@duke.edu organization: Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba 3-8-1, Meguro, Tokyo 153-8902, Japan – sequence: 2 givenname: Takashi surname: Ushida fullname: Ushida, Takashi organization: Biomaterial Center, National Institute for Materials Sciences, Namiki 1-1, Tsukuba, Ibaraki 305-0044, Japan – sequence: 3 givenname: Shigeru surname: Miyaki fullname: Miyaki, Shigeru organization: Division of Biomedical Materials and Systems, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo,Tokyo 113-0033, Japan – sequence: 4 givenname: Hiroshi surname: Akaogi fullname: Akaogi, Hiroshi organization: Division of Biomedical Materials and Systems, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo,Tokyo 113-0033, Japan – sequence: 5 givenname: Kohei surname: Tsuchiya fullname: Tsuchiya, Kohei organization: Biomaterial Center, National Institute for Materials Sciences, Namiki 1-1, Tsukuba, Ibaraki 305-0044, Japan – sequence: 6 givenname: Zhen surname: Yan fullname: Yan, Zhen organization: Department of Orthopedics, Institute of Clinical Medicine, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8575, Japan – sequence: 7 givenname: R. Sanders surname: Williams fullname: Williams, R. Sanders organization: Department of Orthopedics, Institute of Clinical Medicine, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8575, Japan – sequence: 8 givenname: Tetsuya surname: Tateishi fullname: Tateishi, Tetsuya organization: Division of Cardiology, Department of Medicine, Duke University Medical Center, 4321 Medical Park Dr., Suite 200, Durham, NC 27704, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/15721317$$D View this record in MEDLINE/PubMed |
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| Keywords | Wnt10 C2C12 Mechanical stress Mechanical stretch Trans-differentiation Adipocytes Myoblasts |
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| SubjectTerms | Adipocytes Adipocytes - cytology Adipocytes - metabolism Animals Azo Compounds - pharmacology C2C12 Cell Differentiation Cell Line Cell Lineage Cell Membrane - metabolism Intercellular Signaling Peptides and Proteins - metabolism Ligands Mechanical stress Mechanical stretch Mice Myoblasts Myoblasts - cytology Reverse Transcriptase Polymerase Chain Reaction RNA - metabolism RNA, Messenger - metabolism Signal Transduction Stress, Mechanical Trans-differentiation Wnt Proteins Wnt10 |
| Title | Mechanical stretch inhibits myoblast-to-adipocyte differentiation through Wnt signaling |
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