Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis

• Published in: Genes & development Vol. 5; no. 8; pp. 1333 - 1344
• Main Authors: ROSSANT, J, ZIRNGIBL, R, CADO, D, SHAGO, M, GIGUERE, V
• Format: Journal Article
• Language: English
• Published: Cold Spring Harbor, NY Cold Spring Harbor Laboratory 01.08.1991
• Subjects: Animals; beta-Galactosidase - genetics; Biological and medical sciences; Embryo, Mammalian - drug effects; Embryology: invertebrates and vertebrates. Teratology; Female; Fundamental and applied biological sciences. Psychology; Genetic Vectors; Heat-Shock Proteins - genetics; Mice; Mice, Transgenic; Morphogenesis - drug effects; Pregnancy; TATA Box; Teratogens; Teratology. Teratogens; Transcription, Genetic - drug effects; Tretinoin - toxicity; Embryonic development; Rodentia; Transgenic animal; Retinoids; Gene expression; Axial symmetry; Morphogenesis; Vertebrata; Mammalia; Reporter gene; Mouse; Regulatory sequence; Teratogen; Mechanism of action; Retinoic acid

Treatment with retinoic acid (RA) is known to produce complex teratogenic effects in vertebrates, and its presence in the developing embryo as an endogenous substance has led to the suggestion that RA might be a natural morphogenetic agent. Although our understanding of the molecular mechanism of RA...