Results of a phase 1 multicentre investigation of dexmedetomidine bolus and infusion in corrective infant cardiac surgery

• Published in: British journal of anaesthesia : BJA Vol. 123; no. 6; pp. 839 - 852
• Main Authors: Zuppa, Athena F., Nicolson, Susan C., Wilder, Nicole S., Ibla, Juan C., Gottlieb, Erin A., Burns, Kristin M., Stylianou, Mario, Trachtenberg, Felicia, Ni, Hua, Skeen, Tera H., Andropoulos, Dean B.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2019; Elsevier
• Subjects: anaesthesia; Cardiac Surgical Procedures; congenital heart surgery; dexmedetomidine; Dexmedetomidine - administration & dosage; Dexmedetomidine - adverse effects; Dose-Response Relationship, Drug; Female; Heart Defects, Congenital - surgery; Humans; Hypnotics and Sedatives - administration & dosage; Hypnotics and Sedatives - adverse effects; Infant; Infant, Newborn; Infusions, Intravenous; Male; Paediatric Anaesthesia; pharmacokinetics; tetralogy of Fallot; transposition of the great arteries; ventricular septal defect; transposition of the great arteries; dexmedetomidine; congenital heart surgery; pharmacokinetics; ventricular septal defect; tetralogy of Fallot; anaesthesia

Dexmedetomidine (DEX) is increasingly used intraoperatively in infants undergoing cardiac surgery. This phase 1 multicentre study sought to: (i) determine the safety of DEX for cardiac surgery with cardiopulmonary bypass; (ii) determine the pharmacokinetics (PK) of DEX; (iii) create a PK model and d...