Nephrotoxicity assessment of podophyllotoxin-induced rats by regulating PI3K/Akt/mTOR-Nrf2/HO1 pathway in view of toxicological evidence chain (TEC) concept - Kong, Jiao; Kui, Hongqian; Tian, Yue; Kong, Xianbin; He, Tao; Li, Qingbo; Gu, Chunyu; Guo, Jinhe; Liu, Chuanxin (Ecotoxicology and environmental safety, 2023)
Keywords: Autophagy; Nephrotoxic mechanism, Podophyllotoxin; Oxidative stress; PI3K/Akt/mTOR-Nrf2/HO1; Toxicological evidence chain; LPE; Oxidative stress; Scr; Toxicological evidence chain; NS; HO-1; UA; Autophagy; DV; GFR; S1P; PI3K; PPT; Nrf2; AOE; SphK1; mTOR; SL; BUN; GSH; KL; HIE; GTEA; PLA2; SOD; GST; Akt; Nephrotoxic mechanism, Podophyllotoxin; TEC; PC; PAF; TEE; ROS; PI3K/Akt/mTOR-Nrf2/HO1; IPE