Distributional transport kinetics of zidovudine between plasma and brain extracellular fluid/cerebrospinal fluid in the rabbit: investigation of the inhibitory effect of probenecid utilizing microdialysis

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 264; no. 2; pp. 899 - 909
• Main Authors: Wong, S L, Van Belle, K, Sawchuk, R J
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.02.1993; American Society for Pharmacology and Experimental Therapeutics
• Subjects: Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral agents; Biological and medical sciences; Biological Transport - drug effects; Blood-Brain Barrier - drug effects; Brain - metabolism; Dialysis; Extracellular Space - metabolism; Male; Medical sciences; Models, Biological; Pharmacology. Drug treatments; Probenecid - pharmacology; Rabbits; Zidovudine - cerebrospinal fluid; Zidovudine - pharmacokinetics; Drug combination; Intravenous administration; Biological transport; Central nervous system; Rabbit; Cerebrospinal fluid; Lagomorpha; Blood brain barrier; Extracellular fluid; Vertebrata; Mammalia; Animal; Distribution; Antiviral; Drug interaction; Pharmacokinetics; Brain (vertebrata)

The effect of probenecid (PBD) on the distributional transport of zidovudine (AZT) between plasma, cerebrospinal fluid (CSF) and brain extracellular fluid (ECF) was investigated by using microdialysis. New Zealand White rabbits received AZT, in a crossover design, during control and treatment period...