Stereoselective ketamine effect on cardiac output: a population pharmacokinetic/pharmacodynamic modelling study in healthy volunteers

• Published in: British journal of anaesthesia : BJA Vol. 127; no. 1; pp. 23 - 31
• Main Authors: Kamp, Jasper, van Velzen, Monique, Aarts, Leon, Niesters, Marieke, Dahan, Albert, Olofsen, Erik
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2021; Elsevier
• Subjects: cardiac output; Cardiovascular; hydroxynorketamine; ketamine; metabolomics; modeling; NONMEM; norketamine; stereoselectivity; cardiac output; modeling; stereoselectivity; ketamine; metabolomics; hydroxynorketamine; norketamine; NONMEM

Ketamine has cardiac excitatory side-effects. Currently, data on the effects of ketamine and metabolite concentrations on cardiac output are scarce. We therefore developed a pharmacodynamic model derived from data from a randomised clinical trial. The current study is part of a larger clinical study...