Constrained peptides as binding entities

• Published in: Trends in biotechnology (Regular ed.) Vol. 13; no. 10; pp. 426 - 430
• Main Author: Ladner, Robert C.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.10.1995; Elsevier Science
• Subjects: Amino Acid Sequence; Aminoacids, peptides. Hormones. Neuropeptides; Analytical, structural and metabolic biochemistry; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Molecular Sequence Data; Peptides - metabolism; Protein Conformation; Proteins; Ligand binding; Affinity; Specificity; Review; Peptides

Displaying proteins and peptides on genetic packages and selecting packages that display high-affinity binders allows large numbers of peptidyl compounds to be tested for binding to targets. Phage-displayed libraries of unstructured peptides (UPs) have yielded binders for some targets, but not for m...