Constrained peptides as binding entities

Displaying proteins and peptides on genetic packages and selecting packages that display high-affinity binders allows large numbers of peptidyl compounds to be tested for binding to targets. Phage-displayed libraries of unstructured peptides (UPs) have yielded binders for some targets, but not for m...

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Bibliographic Details
Published inTrends in biotechnology (Regular ed.) Vol. 13; no. 10; pp. 426 - 430
Main Author Ladner, Robert C.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.10.1995
Elsevier Science
Subjects
Amino Acid Sequence
Aminoacids, peptides. Hormones. Neuropeptides
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Molecular Sequence Data
Peptides - metabolism
Protein Conformation
Proteins
Ligand binding
Affinity
Specificity
Review
Peptides
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Summary:Displaying proteins and peptides on genetic packages and selecting packages that display high-affinity binders allows large numbers of peptidyl compounds to be tested for binding to targets. Phage-displayed libraries of unstructured peptides (UPs) have yielded binders for some targets, but not for many others. Therefore, more attention is being paid to peptidyl compounds that have varied regions that are subject to conformational constraint.
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ISSN:0167-7799
1879-3096
DOI:10.1016/S0167-7799(00)88997-0