Emerging functions of tissue-resident eosinophils

Eosinophils are typically considered tissue-damaging effector cells in type 2 immune-related diseases. However, they are also increasingly recognized as important modulators of various homeostatic processes, suggesting they retain the ability to adapt their function to different tissue contexts. In...

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Bibliographic Details
Published inThe Journal of experimental medicine Vol. 220; no. 7
Main Authors Gurtner, Alessandra, Crepaz, Daniel, Arnold, Isabelle C.
Format Journal Article
LanguageEnglish
Published United States Rockefeller University Press 03.07.2023
Subjects
Cytokines
Eosinophils
Gastrointestinal Tract
Humans
Immune System Diseases
Mucosal Immunology
Review
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Summary:Eosinophils are typically considered tissue-damaging effector cells in type 2 immune-related diseases. However, they are also increasingly recognized as important modulators of various homeostatic processes, suggesting they retain the ability to adapt their function to different tissue contexts. In this review, we discuss recent progress in our understanding of eosinophil activities within tissues, with particular emphasis on the gastrointestinal tract, where a large population of these cells resides under non-inflammatory conditions. We further examine evidence of their transcriptional and functional heterogeneity and highlight environmental signals emerging as key regulators of their activities, beyond classical type 2 cytokines.
Bibliography:ObjectType-Article-2
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Disclosures: The authors declare no competing interests exist.
ISSN:0022-1007
1540-9538
1540-9538
DOI:10.1084/jem.20221435