Long-term ecological and evolutionary dynamics in the gut microbiomes of carbapenemase-producing Enterobacteriaceae colonized subjects

• Published in: Nature microbiology Vol. 7; no. 10; pp. 1516 - 1524
• Main Authors: Kang, Jonathan T. L., Teo, Jonathan J. Y., Bertrand, Denis, Ng, Amanda, Ravikrishnan, Aarthi, Yong, Melvin, Ng, Oon Tek, Marimuthu, Kalisvar, Chen, Swaine L., Chng, Kern Rei, Gan, Yunn-Hwen, Nagarajan, Niranjan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2022; Nature Publishing Group
• Subjects: 45/22; 45/23; 45/43; 45/77; 631/114/2785; 631/158/855; 631/208/325; 631/326/22/1434; 631/326/2565/2134; Antibiotics; Asymptomatic; Biomedical and Life Sciences; Carbapenemase; Colonization; Commensals; Comparative analysis; Discriminant analysis; Drug resistance; E coli; Ecology; Enterobacteriaceae; Escherichia coli; Genomes; Infections; Infectious Diseases; Inflammation; Intestinal microflora; Klebsiella pneumoniae; Letter; Life Sciences; Medical Microbiology; Metagenomics; Microbiology; Microbiomes; Parasitology; Pathogens; Plasmids; Public health; Taxonomy; Virology; Whole genome sequencing

Long-term colonization of the gut microbiome by carbapenemase-producing Enterobacteriaceae (CPE) is a growing area of public health concern as it can lead to community transmission and rapid increase in cases of life-threatening CPE infections. Here, leveraging the observation that many subjects are...