Toll-like receptors expression and interferon-γ production by NK cells in human sepsis

• Published in: Critical care (London, England) Vol. 16; no. 5; p. R206
• Main Authors: Souza-Fonseca-Guimaraes, Fernando, Parlato, Marianna, Philippart, François, Misset, Benoît, Cavaillon, Jean-Marc, Adib-Conquy, Minou
• Format: Journal Article Web Resource
• Language: English
• Published: England BioMed Central 25.10.2012
• Subjects: Aged; Anesthesia & intensive care; Anesthésie & soins intensifs; Antigens, CD - metabolism; Antigens, Differentiation, T-Lymphocyte - metabolism; Biomarkers - metabolism; Case-Control Studies; CD56 Antigen - metabolism; Cells, Cultured; Female; Flow Cytometry; Human health and pathology; Human health sciences; Humans; Interferon-gamma - metabolism; Killer Cells, Natural - metabolism; Lectins, C-Type - metabolism; Life Sciences; Male; Middle Aged; Sciences de la santé humaine; Sepsis - metabolism; Systemic Inflammatory Response Syndrome - metabolism; Tissues and Organs; Toll-Like Receptors - metabolism

During the course of infection, natural killer (NK) cells contribute to innate immunity by producing cytokines, particularly interferon-gamma (IFN-γ). In addition to their beneficial effects against infection, NK cells may play a detrimental role during systemic inflammation, causing lethality durin...