Angiotensin receptor-binding molecule in leukocytes in association with the systemic and leukocyte inflammatory profile

• Published in: Atherosclerosis Vol. 269; pp. 236 - 244
• Main Authors: Haruhara, Kotaro, Wakui, Hiromichi, Azushima, Kengo, Kurotaki, Daisuke, Kawase, Wataru, Uneda, Kazushi, Haku, Sona, Kobayashi, Ryu, Ohki, Kohji, Kinguchi, Sho, Ohsawa, Masato, Minegishi, Shintaro, Ishigami, Tomoaki, Matsuda, Miyuki, Yamashita, Akio, Nakajima, Hideaki, Tamura, Tomohiko, Tsuboi, Nobuo, Yokoo, Takashi, Tamura, Kouichi
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.02.2018
• Subjects: Adaptor Proteins, Signal Transducing - deficiency; Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Aged; Aged, 80 and over; Animals; Case-Control Studies; Cytokines - genetics; Cytokines - metabolism; Disease Models, Animal; Female; Humans; Inflammation; Inflammation - chemically induced; Inflammation - genetics; Inflammation - immunology; Inflammation - metabolism; Inflammation Mediators - metabolism; Leukocyte; Leukocytes - immunology; Leukocytes - metabolism; Lipopolysaccharides; Male; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Non-communicable diseases; Noncommunicable Diseases; Receptor; Renin-angiotensin system; NCDs; baPWV; MCP-1; Leukocyte; RAS; ABI; LPS; ddPCR; ATRAP; (P)RR; BM-WT; UACR; CKD; RT-qPCR; eGFR; ACE; BM-KO; Inflammation; AT1R; Renin-angiotensin system; IL-1β; UUO; Non-communicable diseases; TNF-α; Receptor; hsCRP

The components of the renin-angiotensin system in leukocytes is involved in the pathophysiology of non-communicable diseases (NCDs), including hypertension, atherosclerosis and chronic kidney disease. Angiotensin II type 1 receptor (AT1R)-associated protein (ATRAP) is an AT1R-specific binding protei...