Darwinian and demographic forces affecting human protein coding genes

• Published in: Genome Research Vol. 19; no. 5; pp. 838 - 849
• Main Authors: Nielsen, Rasmus, Hubisz, Melissa J., Hellmann, Ines, Torgerson, Dara, Andrés, Aida M., Albrechtsen, Anders, Gutenkunst, Ryan, Adams, Mark D., Cargill, Michele, Boyko, Adam, Indap, Amit, Bustamante, Carlos D., Clark, Andrew G.
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.05.2009
• Subjects: Black or African American - genetics; Demography; Evolution, Molecular; Gene Frequency; Genetic Variation; Genetics, Population; Genome, Human; Humans; Letter; MicroRNAs - genetics; Polymorphism, Single Nucleotide; Proteins - genetics; Selection, Genetic; White People - genetics

Past demographic changes can produce distortions in patterns of genetic variation that can mimic the appearance of natural selection unless the demographic effects are explicitly removed. Here we fit a detailed model of human demography that incorporates divergence, migration, admixture, and changes...