Quality of FDM 3D Printed Medicines for Pediatrics: Considerations for Formulation Development, Filament Extrusion, Printing Process and Printer Design

• Published in: Therapeutic innovation & regulatory science Vol. 56; no. 6; pp. 910 - 928
• Main Authors: Quodbach, Julian, Bogdahn, Malte, Breitkreutz, Jörg, Chamberlain, Rebecca, Eggenreich, Karin, Elia, Alessandro Giuseppe, Gottschalk, Nadine, Gunkel-Grabole, Gesine, Hoffmann, Lena, Kapote, Dnyaneshwar, Kipping, Thomas, Klinken, Stefan, Loose, Fabian, Marquetant, Tristan, Windolf, Hellen, Geißler, Simon, Spitz, Tilmann
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.11.2022; Springer Nature B.V
• Subjects: 3-D printers; Analytical methods; Consortia; Design; Dosage; Drug dosages; Drug Safety and Pharmacovigilance; Extrusion; Filaments; Fused deposition modeling; Intermediates; Manufacturing; Medicine; New technology; Optimization; Patients; Pediatrics; Pharmacotherapy; Pharmacy; Polymers; Precision medicine; Printing; Process control; Process controls; Process parameters; Quality assurance; Quality management; Review; Three dimensional printing

3d printing is capable of providing dose individualization for pediatric medicines and translating the precision medicine approach into practical application. In pediatrics, dose individualization and preparation of small dosage forms is a requirement for successful therapy, which is frequently not...