Aversive Learning Increases Release Probability of Olfactory Sensory Neurons

• Published in: Current biology Vol. 30; no. 1; pp. 31 - 41.e3
• Main Authors: Bhattarai, Janardhan P., Schreck, Mary, Moberly, Andrew H., Luo, Wenqin, Ma, Minghong
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 06.01.2020
• Subjects: Animals; Conditioning, Operant; external tufted cells; Fear; fear learning; Female; GABAB receptor; glomeruli; Learning; Male; Mice; olfactory bulb; Olfactory Bulb - physiology; Olfactory Nerve - physiology; olfactory sensory neurons; optogenetics; paired-pulse ratio; release probability; olfactory bulb; glomeruli; fear learning; optogenetics; external tufted cells; olfactory sensory neurons; GABAB receptor; paired-pulse ratio; release probability
• ISSN: 0960-9822; 1879-0445; 1879-0445
• DOI: 10.1016/j.cub.2019.11.006

Predicting danger from previously associated sensory stimuli is essential for survival. Contributions from altered peripheral sensory inputs are implicated in this process, but the underlying mechanisms remain elusive. Here, we use the mammalian olfactory system to investigate such mechanisms. Prima...