Diabetes and kidney dysfunction markedly alter the content of sphingolipids carried by circulating lipoproteins

• Published in: Journal of clinical lipidology Vol. 16; no. 2; pp. 173 - 183
• Main Authors: Hammad, Samar M, Hunt, Kelly J, Baker, Nathaniel L, Klein, Richard L, Lopes-Virella, Maria F
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2022
• Subjects: Albuminuria; Ceramide; Dihydrosphingosine; Glycosphingolipid; Hexosylceramide; Lactosylceramide; Macroalbuminuria; Sphingolipid; Sphingomyelin; Sphingosine; Type 2 diabetes; Type 2 diabetes; eGFR; ESRD; Lactosylceramide; Sphingolipid; Albuminuria; AER; Cer; S1P; Dihydrosphingosine; Hex-Cer; MA; Glycosphingolipid; dhsph; Hexosylceramide; Sphingosine; Sphingomyelin; Ceramide; Lac-Cer; SM; dhsph-1; Macroalbuminuria

•Assessing sphingolipid distribution in plasma lipoproteins is clinically valuable.•Plasma levels do not consistently reflect changes in circulating lipoproteins.•HDL sphingolipids are significantly lower in diabetes than in controls.•LDL sphingomyelins are higher in patients with diabetes and macro...