Cells Under Stress: An Inertial-Shear Microfluidic Determination of Cell Behavior

• Published in: Biophysical journal Vol. 116; no. 6; pp. 1127 - 1135
• Main Authors: Armistead, Fern J., Gala De Pablo, Julia, Gadêlha, Hermes, Peyman, Sally A., Evans, Stephen D.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 19.03.2019; The Biophysical Society
• Subjects: Biomechanical Phenomena; Cell Line; Cytological Techniques - instrumentation; Elastic Modulus; Humans; Lab-On-A-Chip Devices; Phenotype; Shear Strength; Stress, Mechanical

The deformability of a cell is the direct result of a complex interplay between the different constituent elements at the subcellular level, coupling a wide range of mechanical responses at different length scales. Changes to the structure of these components can also alter cell phenotype, which poi...