A multiscale whole-cell theory for mechanosensitive migration on viscoelastic substrates

• Published in: Biophysical journal Vol. 122; no. 1; pp. 114 - 129
• Main Authors: Shu, Wenya, Kaplan, C. Nadir
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 03.01.2023; The Biophysical Society
• Subjects: Cell Movement; Cytoskeleton; Extracellular Matrix - metabolism; Focal Adhesions; Signal Transduction

Increasing experimental evidence validates that both the elastic stiffness and viscosity of the extracellular matrix regulate mesenchymal cell behavior, such as the rational switch between durotaxis (cell migration to stiffer regions), anti-durotaxis (migration to softer regions), and adurotaxis (st...