Kigelia africana inhibits proliferation and induces cell death in stage 4 Neuroblastoma cell lines
Neuroblastoma (NB) is one of the most common solid pediatric tumors and especially high-risk NBs still account for about 12–15% of cancer related deaths in children. Kigelia africana (KA) is a plant used in traditional African medicine which has already shown its anti-cancer potential in several in...
Saved in:
Published in | Biomedicine & pharmacotherapy Vol. 154; p. 113584 |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier Masson SAS
01.10.2022
Elsevier |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Neuroblastoma (NB) is one of the most common solid pediatric tumors and especially high-risk NBs still account for about 12–15% of cancer related deaths in children. Kigelia africana (KA) is a plant used in traditional African medicine which has already shown its anti-cancer potential in several in vitro and in vivo studies. The aim of this study is to evaluate the effect of KA fruit extract on stage 4 high-risk NB cells. Therefore, NB cell lines with and without MYCN amplification and non-neoplastic cells were treated with KA fruit extract at different concentrations. The effect of KA on cell viability and apoptosis rate were assessed by bioluminescence-/fluorescence-based assays. Several proteins involved in survival, tumor growth, inflammation and metastasis were detected via western blot and immunofluorescence. Secreted cytokines were detected via ELISA. Phytochemical composition of the extract was analyzed by liquid chromatography with tandem mass spectrometry (LC/MS/MS). Our group demonstrates a dose- and time-dependent selective cytotoxic effect of KA fruit extract on NB, especially in MYCN non-amplified tumor cells, by inhibiting cell proliferation and inducing cell death. Western blot and immunofluorescence results demonstrate a regulation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), disialoganglioside GD2 and epidermal growth factor receptor (EGFR) in KA-treated tumor cells. Our results evidence striking anti-cancer properties of KA fruit and pave the way for further surveys on the therapeutic properties and mechanisms of action in NB.
[Display omitted]
•Kigelia africana (KA) is a medicinal plant with anti-cancer effects.•KA has selective cytotoxic effects on high-risk neuroblastoma cells.•KA inhibits proliferation and induces cell death in neuroblastoma cells.•KA modulates protein expression and signaling pathways in neuroblastoma cells. |
---|---|
AbstractList | Neuroblastoma (NB) is one of the most common solid pediatric tumors and especially high-risk NBs still account for about 12–15% of cancer related deaths in children. Kigelia africana (KA) is a plant used in traditional African medicine which has already shown its anti-cancer potential in several in vitro and in vivo studies. The aim of this study is to evaluate the effect of KA fruit extract on stage 4 high-risk NB cells. Therefore, NB cell lines with and without MYCN amplification and non-neoplastic cells were treated with KA fruit extract at different concentrations. The effect of KA on cell viability and apoptosis rate were assessed by bioluminescence-/fluorescence-based assays. Several proteins involved in survival, tumor growth, inflammation and metastasis were detected via western blot and immunofluorescence. Secreted cytokines were detected via ELISA. Phytochemical composition of the extract was analyzed by liquid chromatography with tandem mass spectrometry (LC/MS/MS). Our group demonstrates a dose- and time-dependent selective cytotoxic effect of KA fruit extract on NB, especially in MYCN non-amplified tumor cells, by inhibiting cell proliferation and inducing cell death. Western blot and immunofluorescence results demonstrate a regulation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), disialoganglioside GD2 and epidermal growth factor receptor (EGFR) in KA-treated tumor cells. Our results evidence striking anti-cancer properties of KA fruit and pave the way for further surveys on the therapeutic properties and mechanisms of action in NB.
[Display omitted]
•Kigelia africana (KA) is a medicinal plant with anti-cancer effects.•KA has selective cytotoxic effects on high-risk neuroblastoma cells.•KA inhibits proliferation and induces cell death in neuroblastoma cells.•KA modulates protein expression and signaling pathways in neuroblastoma cells. Neuroblastoma (NB) is one of the most common solid pediatric tumors and especially high-risk NBs still account for about 12–15% of cancer related deaths in children. Kigelia africana (KA) is a plant used in traditional African medicine which has already shown its anti-cancer potential in several in vitro and in vivo studies. The aim of this study is to evaluate the effect of KA fruit extract on stage 4 high-risk NB cells. Therefore, NB cell lines with and without MYCN amplification and non-neoplastic cells were treated with KA fruit extract at different concentrations. The effect of KA on cell viability and apoptosis rate were assessed by bioluminescence-/fluorescence-based assays. Several proteins involved in survival, tumor growth, inflammation and metastasis were detected via western blot and immunofluorescence. Secreted cytokines were detected via ELISA. Phytochemical composition of the extract was analyzed by liquid chromatography with tandem mass spectrometry (LC/MS/MS). Our group demonstrates a dose- and time-dependent selective cytotoxic effect of KA fruit extract on NB, especially in MYCN non-amplified tumor cells, by inhibiting cell proliferation and inducing cell death. Western blot and immunofluorescence results demonstrate a regulation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), disialoganglioside GD2 and epidermal growth factor receptor (EGFR) in KA-treated tumor cells. Our results evidence striking anti-cancer properties of KA fruit and pave the way for further surveys on the therapeutic properties and mechanisms of action in NB. |
ArticleNumber | 113584 |
Author | Dücker, Charlotte Oliver Grau, Albert Appl, Birgit Pagerols Raluy, Laia Reinshagen, Konrad Ahrens, Sofia Trochimiuk, Magdalena Feixas Serra, Gemma |
Author_xml | – sequence: 1 givenname: Sofia surname: Ahrens fullname: Ahrens, Sofia email: sofia-marie.ahrens@stud.uke.uni-hamburg.de organization: Department of Pediatric Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany – sequence: 2 givenname: Birgit surname: Appl fullname: Appl, Birgit email: b.appl@uke.de organization: Department of Pediatric Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany – sequence: 3 givenname: Magdalena surname: Trochimiuk fullname: Trochimiuk, Magdalena email: m.trochimiuk@uke.de organization: Department of Pediatric Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany – sequence: 4 givenname: Charlotte surname: Dücker fullname: Dücker, Charlotte email: charlotte.duecker@online.de organization: Department of Pediatric Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany – sequence: 5 givenname: Gemma surname: Feixas Serra fullname: Feixas Serra, Gemma organization: Institut Bonanova, Circumval·lació 8, 08003 Barcelona, Spain – sequence: 6 givenname: Albert surname: Oliver Grau fullname: Oliver Grau, Albert email: aoliver@institutbonanova.cat organization: Institut Bonanova, Circumval·lació 8, 08003 Barcelona, Spain – sequence: 7 givenname: Konrad surname: Reinshagen fullname: Reinshagen, Konrad email: k.reinshagen@uke.de organization: Department of Pediatric Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany – sequence: 8 givenname: Laia surname: Pagerols Raluy fullname: Pagerols Raluy, Laia email: l.pagerols-raluy@uke.de organization: Department of Pediatric Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany |
BookMark | eNp9kU1vEzEQhi3USqSl_4CDj1w2-Hu9FyRUQamo4ELP1tgeJ44262BvkPj33bCII6eRZt555uO9IVdTmZCQt5xtOePm_WHrczntYSuYEFvOpbbqFdnwQbPOMNZfkQ3rteykFOI1uWntwBjTRtoN8V_zDscMFFLNASagedpnn-dGT7WMOWGFOZeJwhSXUjwHbDTgONKIMO-XFG0z7JAq-g3PtfgR2lyOsGrGPGF7Q64TjA3v_sZb8vz504_7L93T94fH-49PXVCazx1EJlPQHhJG7VEr7xFiSjYMyngbrQqQhoErHqUeYq8GY6QRPTBvPWdR3pLHlRsLHNyp5iPU365Adn8Spe4c1DmHEV0A5H4QBpQFFQdhdWAL34CVIlqpFta7lbU84ecZ2-yOuV1OggnLuTnRs97wXvVikapVGmpprWL6N5ozd7HHHdxqj7vY41Z7lrYPaxsuL_mVsboWMk4BY64Y5mXn_H_ACz53nSw |
CitedBy_id | crossref_primary_10_1016_j_sajb_2023_10_001 crossref_primary_10_1007_s11101_024_09957_5 crossref_primary_10_3390_biom13030563 |
Cites_doi | 10.1056/NEJMra0707704 10.1016/j.jep.2016.05.049 10.3390/biom10040502 10.1016/j.yexcr.2017.04.016 10.1111/bph.15030 10.1200/JCO.19.01410 10.3389/fonc.2021.692142 10.2174/156800908786241050 10.1016/j.ebiom.2019.10.041 10.2174/1871520611313040005 10.1158/1078-0432.CCR-08-0821 10.3389/fimmu.2014.00325 10.1371/journal.pone.0059632 10.3390/ijms21020401 10.1038/sj.cgt.7700749 10.1016/S0140-6736(07)60983-0 10.1021/acs.jnatprod.5b01055 10.1046/j.1432-1327.2000.01421.x 10.1200/JCO.2008.17.5877 10.1038/nrdp.2016.78 10.3390/molecules26216452 10.1038/35009130 10.1200/JCO.2008.16.6876 10.3390/diseases9040078 10.2147/BCTT.S144202 10.1148/radiol.11101352 10.1093/abbs/gmw064 10.1158/0008-5472.CAN-04-2426 10.1111/bcpt.13077 10.1200/JCO.2014.59.4648 10.1074/jbc.M203891200 10.3389/fonc.2020.01000 10.1016/j.biopha.2019.108612 10.3390/biom10010032 10.1038/nature04870 10.1111/jcmm.14884 10.1002/wsbm.1331 10.1517/14728222.2014.986459 10.3389/fphar.2019.01614 10.3390/plants9060753 10.12659/MSM.920095 10.1055/s-0043-103086 10.1016/j.radonc.2013.06.010 10.1007/s10549-005-9011-0 10.1200/JCO.1993.11.8.1466 10.1002/ijc.2910520407 10.1038/sj.bjc.6602941 10.1080/19420862.2017.1402997 10.3892/ijmm.2014.2032 |
ContentType | Journal Article |
Copyright | 2022 The Authors |
Copyright_xml | – notice: 2022 The Authors |
DBID | 6I. AAFTH AAYXX CITATION 7X8 DOA |
DOI | 10.1016/j.biopha.2022.113584 |
DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef MEDLINE - Academic DOAJ Directory of Open Access Journals |
DatabaseTitle | CrossRef MEDLINE - Academic |
DatabaseTitleList | |
Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Pharmacy, Therapeutics, & Pharmacology |
EISSN | 1950-6007 |
EndPage | 113584 |
ExternalDocumentID | oai_doaj_org_article_cae1b926a48a4d9285c084c6a832d834 10_1016_j_biopha_2022_113584 S0753332222009738 |
GroupedDBID | --- --K --M .1- .FO .GJ .~1 0R~ 0SF 1B1 1P~ 1RT 1~. 1~5 23N 4.4 457 4CK 4G. 53G 5GY 5RE 5VS 6I. 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAFTH AAFWJ AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATCM AAXUO ABBQC ABFNM ABLVK ABMAC ABMZM ABXDB ABYKQ ABZDS ACDAQ ACIUM ACRLP ADBBV ADEZE ADMUD AEBSH AEKER AENEX AEVXI AFCTW AFKWA AFPKN AFRHN AFTJW AFXIZ AGHFR AGUBO AGYEJ AHHHB AI. AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY AJUYK ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA GROUPED_DOAJ HMT HVGLF HZ~ IHE J1W KOM LCYCR M34 M41 MO0 N9A NCXOZ O-L O9- OAUVE OD~ OGGZJ OK1 OO0 OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SDF SDG SDP SEM SES SEW SPT SSH SSP SSZ T5K VH1 WUQ Z5R ~02 ~G- AAXKI AAYXX ADVLN AKRWK CITATION 7X8 |
ID | FETCH-LOGICAL-c451t-ad03fc5bafed5be54bbeadff8c946b8d84caf99141d359d749663627a0b8b10d3 |
IEDL.DBID | DOA |
ISSN | 0753-3322 |
IngestDate | Thu Jul 04 21:08:26 EDT 2024 Fri Aug 16 05:15:17 EDT 2024 Thu Sep 12 17:42:31 EDT 2024 Fri Feb 23 02:38:14 EST 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | Kigelia africana NF-κB Phytotherapeutics Neuroblastoma EGFR Cancer |
Language | English |
License | This is an open access article under the CC BY-NC-ND license. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c451t-ad03fc5bafed5be54bbeadff8c946b8d84caf99141d359d749663627a0b8b10d3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
OpenAccessLink | https://doaj.org/article/cae1b926a48a4d9285c084c6a832d834 |
PQID | 2707617472 |
PQPubID | 23479 |
PageCount | 1 |
ParticipantIDs | doaj_primary_oai_doaj_org_article_cae1b926a48a4d9285c084c6a832d834 proquest_miscellaneous_2707617472 crossref_primary_10_1016_j_biopha_2022_113584 elsevier_sciencedirect_doi_10_1016_j_biopha_2022_113584 |
PublicationCentury | 2000 |
PublicationDate | October 2022 2022-10-00 20221001 2022-10-01 |
PublicationDateYYYYMMDD | 2022-10-01 |
PublicationDate_xml | – month: 10 year: 2022 text: October 2022 |
PublicationDecade | 2020 |
PublicationTitle | Biomedicine & pharmacotherapy |
PublicationYear | 2022 |
Publisher | Elsevier Masson SAS Elsevier |
Publisher_xml | – name: Elsevier Masson SAS – name: Elsevier |
References | Park, Cheung (bib15) 2020; 38 Jia, Zhu, Yang, Ma, Pu, Han (bib28) 2020; 24 Pastore, Lulli, Maurelli, Dellambra, De Luca, Korkina (bib52) 2013; 8 Tsai, Tsai, Tsai, Chen, Hsieh, Chen (bib55) 2021; 26 Bhattamisra, Yap, Rao, Choudhury (bib27) 2019; 10 Kartikasari, Huertas, Mitchell, Plebanski (bib48) 2021; 11 De Bernardi, Gerrard, Boni, Rubie, Cañete, Di Cataldo (bib10) 2009; 27 Karacay, Sanlioglu, Griffith, Sandler, Bonthius (bib42) 2004; 11 Luo, Zhu, Tong, Peng (bib30) 2020; 26 Megison, Gillory, Beierle (bib14) 2013; 13 Jackson, Ceresa (bib44) 2017 Lee, Ryu, Kim, Kim, Oh, Ahn (bib32) 2020; 10 Choudhari, Mandave, Deshpande, Ranjekar, Prakash (bib34) 2019; 10 Maris, Hogarty, Bagatell, Cohn (bib2) 2007; 369 Pinto, Applebaum, Volchenboum, Matthay, London, Ambros (bib12) 2015; 33 Ho, Minturn, Hishiki, Zhao, Wang, Cnaan (bib13) 2005; 65 Simon, Hero, Schulte, Deubzer, Hundsdoerfer, Von Schweinitz (bib7) 2017; 229 Ryan, Ernst, Rice, Vousden (bib19) 2000; 404 Suzuki, Cheung (bib25) 2015; 19 Zhi, Lu, Duan, Sun, Guan, Dong (bib39) 2015; 35 Anson, Wilcox, Huseman, Stump, Paris, Darkwah (bib53) 2018; 123 Zhou, Yang, Park, Nguyen, Seo, Lee (bib50) 2017; 7 Krengel, Bousquet (bib24) 2014; 5 Karin (bib18) 2006; 441 Cook (bib54) 2018; 10 Lin, Shi, Wang, Shen (bib29) 2008; 8 Nazha, Inal, Owonikoko (bib23) 2020; 10 Zheng, Shen, Li, Zheng, Zong, Ye (bib21) 2016; 48 Kaltschmidt, Kaltschmidt, Hofmann, Hehner, Dröge, Schmitz (bib41) 2000; 267 Costea, Vlad, Miclea, Ganea, Szöllősi, Mocanu (bib31) 2020; 21 Lo, Hsu, Hung (bib46) 2006; 95 Vega, Colmenero-Repiso, Gómez-Muñoz, Rodríguez-Prieto, Aguilar-Morante, Ramírez (bib16) 2019; 49 Yu, Lin, Zhang, Zhang, Hu (bib38) 2020; 5 Matthay, Maris, Schleiermacher, Nakagawara, Mackall, Diller (bib3) 2016; 2 Velmurugan, Lin, Mahalakshmi, Chuang, Lin, Lo (bib49) 2020; 10 Bello, Shehu, Musa, Zaini Asmawi, Mahmud (bib35) 2016; 189 Stiller, Parkin (bib1) 1992; 52 Monclair, Brodeur, Ambros, Brisse, Cecchetto, Holmes (bib6) 2009; 27 Otte, Dyberg, Pepich, Johnsen (bib11) 2020; 10 Brand, Iida, Luthar, Starr, Huppert, Wheeler (bib47) 2013; 108 Newman, Cragg (bib33) 2016; 79 Brisse, McCarville, Granata, Krug, Wootton-Gorges, Kanegawa (bib4) 2011; 261 Ciardiello, Tortora (bib20) 2008; 358 Brodeur, Pritchard, Berthold, Carlsen, Castel, Castelberry (bib5) 1993; 11 Braoudaki, Hatziagapiou, Zaravinos, Lambrou (bib8) 2021; 9 Nabatanzi, Nkadimeng S, Lall, Kabasa, Mcgaw (bib26) 2020; 9 Imran, Rauf, Abu-Izneid, Nadeem, Shariati, Khan (bib36) 2019; 112 Bian, Opipari, Ratanaproeksa, Boitano, Lucas, Castle (bib43) 2002; 277 Mueller, Ehlert, Endres, Pill, Siebert, Kietz (bib9) 2018; 10 Yang, Wang, Wang, Cheng, Lin, Feng (bib40) 2015; 10 Wang, Wang, Chen, Fu, Wang, Fei (bib51) 2020; 177 Mitchell, Vargas, Hoffmann (bib17) 2016; 8 Dhanasekaran, Deutzmann, Mahauad-Fernandez, Hansen, Gouw, Felsher (bib37) 2021 Michaelis, Bliss, Arnold, Hinsch, Rothweiler, Deubzer (bib22) 2008; 14 Lo, Hung (bib45) 2006; 94 Mitchell (10.1016/j.biopha.2022.113584_bib17) 2016; 8 Mueller (10.1016/j.biopha.2022.113584_bib9) 2018; 10 Ryan (10.1016/j.biopha.2022.113584_bib19) 2000; 404 Michaelis (10.1016/j.biopha.2022.113584_bib22) 2008; 14 Choudhari (10.1016/j.biopha.2022.113584_bib34) 2019; 10 Lo (10.1016/j.biopha.2022.113584_bib46) 2006; 95 Cook (10.1016/j.biopha.2022.113584_bib54) 2018; 10 Brisse (10.1016/j.biopha.2022.113584_bib4) 2011; 261 Newman (10.1016/j.biopha.2022.113584_bib33) 2016; 79 De Bernardi (10.1016/j.biopha.2022.113584_bib10) 2009; 27 Dhanasekaran (10.1016/j.biopha.2022.113584_bib37) 2021 Otte (10.1016/j.biopha.2022.113584_bib11) 2020; 10 Monclair (10.1016/j.biopha.2022.113584_bib6) 2009; 27 Maris (10.1016/j.biopha.2022.113584_bib2) 2007; 369 Kartikasari (10.1016/j.biopha.2022.113584_bib48) 2021; 11 Lo (10.1016/j.biopha.2022.113584_bib45) 2006; 94 Brand (10.1016/j.biopha.2022.113584_bib47) 2013; 108 Velmurugan (10.1016/j.biopha.2022.113584_bib49) 2020; 10 Anson (10.1016/j.biopha.2022.113584_bib53) 2018; 123 Zheng (10.1016/j.biopha.2022.113584_bib21) 2016; 48 Bian (10.1016/j.biopha.2022.113584_bib43) 2002; 277 Stiller (10.1016/j.biopha.2022.113584_bib1) 1992; 52 Vega (10.1016/j.biopha.2022.113584_bib16) 2019; 49 Suzuki (10.1016/j.biopha.2022.113584_bib25) 2015; 19 Ho (10.1016/j.biopha.2022.113584_bib13) 2005; 65 Costea (10.1016/j.biopha.2022.113584_bib31) 2020; 21 Karacay (10.1016/j.biopha.2022.113584_bib42) 2004; 11 Lin (10.1016/j.biopha.2022.113584_bib29) 2008; 8 Kaltschmidt (10.1016/j.biopha.2022.113584_bib41) 2000; 267 Jackson (10.1016/j.biopha.2022.113584_bib44) 2017 Pinto (10.1016/j.biopha.2022.113584_bib12) 2015; 33 Krengel (10.1016/j.biopha.2022.113584_bib24) 2014; 5 Bhattamisra (10.1016/j.biopha.2022.113584_bib27) 2019; 10 Lee (10.1016/j.biopha.2022.113584_bib32) 2020; 10 Nabatanzi (10.1016/j.biopha.2022.113584_bib26) 2020; 9 Matthay (10.1016/j.biopha.2022.113584_bib3) 2016; 2 Simon (10.1016/j.biopha.2022.113584_bib7) 2017; 229 Yang (10.1016/j.biopha.2022.113584_bib40) 2015; 10 Luo (10.1016/j.biopha.2022.113584_bib30) 2020; 26 Imran (10.1016/j.biopha.2022.113584_bib36) 2019; 112 Nazha (10.1016/j.biopha.2022.113584_bib23) 2020; 10 Yu (10.1016/j.biopha.2022.113584_bib38) 2020; 5 Pastore (10.1016/j.biopha.2022.113584_bib52) 2013; 8 Tsai (10.1016/j.biopha.2022.113584_bib55) 2021; 26 Zhi (10.1016/j.biopha.2022.113584_bib39) 2015; 35 Karin (10.1016/j.biopha.2022.113584_bib18) 2006; 441 Park (10.1016/j.biopha.2022.113584_bib15) 2020; 38 Ciardiello (10.1016/j.biopha.2022.113584_bib20) 2008; 358 Zhou (10.1016/j.biopha.2022.113584_bib50) 2017; 7 Megison (10.1016/j.biopha.2022.113584_bib14) 2013; 13 Jia (10.1016/j.biopha.2022.113584_bib28) 2020; 24 Wang (10.1016/j.biopha.2022.113584_bib51) 2020; 177 Braoudaki (10.1016/j.biopha.2022.113584_bib8) 2021; 9 Bello (10.1016/j.biopha.2022.113584_bib35) 2016; 189 Brodeur (10.1016/j.biopha.2022.113584_bib5) 1993; 11 |
References_xml | – volume: 26 start-page: 6452 year: 2021 ident: bib55 article-title: Luteolin inhibits breast cancer stemness and enhances chemosensitivity through the Nrf2-mediated pathway publication-title: Molecules contributor: fullname: Chen – volume: 65 start-page: 9868 year: 2005 end-page: 9875 ident: bib13 article-title: Proliferation of human neuroblastomas mediated by the epidermal growth factor receptor publication-title: Cancer Res. contributor: fullname: Cnaan – volume: 229 start-page: 147 year: 2017 end-page: 167 ident: bib7 article-title: GPOH guidelines for diagnosis and treatment of patients with neuroblastic tumors publication-title: Klin. Padiatr. contributor: fullname: Von Schweinitz – volume: 177 start-page: 3009 year: 2020 end-page: 3023 ident: bib51 article-title: A low MW inhibitor of CD44 dimerization for the treatment of glioblastoma publication-title: Br. J. Pharm. contributor: fullname: Fei – volume: 21 start-page: 401 year: 2020 ident: bib31 article-title: Alleviation of multidrug resistance by flavonoid and non-flavonoid compounds in breast, lung, colorectal and prostate cancer publication-title: Int. J. Mol. Sci. contributor: fullname: Mocanu – volume: 94 start-page: 184 year: 2006 end-page: 188 ident: bib45 article-title: Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival publication-title: Br. J. Cancer contributor: fullname: Hung – volume: 108 start-page: 370 year: 2013 end-page: 377 ident: bib47 article-title: Nuclear EGFR as a molecular target in cancer publication-title: Radio. Oncol. contributor: fullname: Wheeler – volume: 7 year: 2017 ident: bib50 article-title: The lichen secondary metabolite atranorin suppresses lung cancer cell motility and tumorigenesis publication-title: Sci. Rep. contributor: fullname: Lee – volume: 24 start-page: 2901 year: 2020 end-page: 2916 ident: bib28 article-title: Verbascoside inhibits progression of glioblastoma cells by promoting Let-7g-5p and down-regulating HMGA2 via Wnt/beta-catenin signalling blockade publication-title: J. Cell Mol. Med. contributor: fullname: Han – volume: 267 start-page: 3828 year: 2000 end-page: 3835 ident: bib41 article-title: The pro- or anti-apoptotic function of NF-κB is determined by the nature of the apoptotic stimulus publication-title: Eur. J. Biochem. contributor: fullname: Schmitz – volume: 261 start-page: 243 year: 2011 end-page: 257 ident: bib4 article-title: Guidelines for imaging and staging of neuroblastic tumors: consensus report from the international neuroblastoma risk group project publication-title: Radiology contributor: fullname: Kanegawa – volume: 9 start-page: 78 year: 2021 ident: bib8 article-title: MYCN in Neuroblastoma: “Old Wine into New Wineskins” publication-title: Diseases contributor: fullname: Lambrou – volume: 369 start-page: 2106 year: 2007 end-page: 2120 ident: bib2 article-title: Neuroblastoma publication-title: Lancet contributor: fullname: Cohn – volume: 8 start-page: 634 year: 2008 end-page: 646 ident: bib29 article-title: Luteolin a flavonoid with potential for cancer prevention and therapy publication-title: Curr. Cancer Drug Targets contributor: fullname: Shen – volume: 112 year: 2019 ident: bib36 article-title: Luteolin, a flavonoid, as an anticancer agent: a review publication-title: Biomed. Pharm. contributor: fullname: Khan – volume: 441 start-page: 431 year: 2006 end-page: 436 ident: bib18 article-title: Nuclear factor-κB in cancer development and progression publication-title: Nature contributor: fullname: Karin – volume: 10 year: 2015 ident: bib40 article-title: NF-κB regulates caspase-4 expression and sensitizes neuroblastoma cells to fas-induced apoptosis publication-title: PLoS One contributor: fullname: Feng – volume: 49 start-page: 82 year: 2019 end-page: 95 ident: bib16 article-title: CD44-high neural crest stem-like cells are associated with tumour aggressiveness and poor survival in neuroblastoma tumours publication-title: EBioMedicine contributor: fullname: Ramírez – volume: 52 start-page: 538 year: 1992 end-page: 543 ident: bib1 article-title: International variations in the incidence of neuroblastoma publication-title: Int. J. Cancer contributor: fullname: Parkin – volume: 13 start-page: 563 year: 2013 end-page: 575 ident: bib14 article-title: Cell survival signaling in neuroblastoma publication-title: Anti Cancer Agents Med Chem. contributor: fullname: Beierle – volume: 27 start-page: 298 year: 2009 end-page: 303 ident: bib6 article-title: The International neuroblastoma risk group (INRG) staging system: an INRG task force report publication-title: J. Clin. Oncol. contributor: fullname: Holmes – volume: 10 year: 2020 ident: bib11 article-title: MYCN function in neuroblastoma development publication-title: Front Oncol. contributor: fullname: Johnsen – volume: 10 start-page: 502 year: 2020 ident: bib49 article-title: Luteolin-7-O-glucoside inhibits oral cancer cell migration and invasion by regulating matrix metalloproteinase-2 expression and extracellular signal-regulated kinase pathway publication-title: Biomolecules contributor: fullname: Lo – volume: 35 start-page: 349 year: 2015 end-page: 357 ident: bib39 article-title: Involvement of the nuclear factor-κB signaling pathway in the regulation of CXC chemokine receptor-4 expression in neuroblastoma cells induced by tumor necrosis factor-α publication-title: Int. J. Mol. Med. contributor: fullname: Dong – volume: 2 start-page: 16078 year: 2016 ident: bib3 article-title: Neuroblastoma publication-title: Nat. Rev. Dis. Prim. contributor: fullname: Diller – volume: 358 start-page: 1160 year: 2008 end-page: 1174 ident: bib20 article-title: EGFR antagonists in cancer treatment publication-title: New Engl. J. Med. contributor: fullname: Tortora – volume: 48 start-page: 762 year: 2016 end-page: 767 ident: bib21 article-title: Epidermal growth factor receptor is overexpressed in neuroblastoma tissues and cells publication-title: Acta Biochim Biophys. Sin. contributor: fullname: Ye – volume: 189 start-page: 253 year: 2016 end-page: 276 ident: bib35 article-title: Kigelia africana (Lam.) Benth. (Sausage tree): phytochemistry and pharmacological review of a quintessential African traditional medicinal plant publication-title: J. Ethnopharmacol. contributor: fullname: Mahmud – volume: 19 start-page: 349 year: 2015 end-page: 362 ident: bib25 article-title: Disialoganglioside GD2 as a therapeutic target for human diseases publication-title: Expert Opin. Ther. Targets contributor: fullname: Cheung – volume: 10 year: 2020 ident: bib32 article-title: Verminoside from Pseudolysimachion rotundum var. subintegrum sensitizes cisplatin-resistant cancer cells and suppresses metastatic growth of human breast cancer publication-title: Sci. Rep. contributor: fullname: Ahn – volume: 95 start-page: 211 year: 2006 end-page: 218 ident: bib46 article-title: EGFR signaling pathway in breast cancers: from traditional signal transduction to direct nuclear translocalization publication-title: Breast Cancer Res Treat. contributor: fullname: Hung – volume: 11 year: 2021 ident: bib48 article-title: Tumor-induced inflammatory cytokines and the emerging diagnostic devices for cancer detection and prognosis publication-title: Front Oncol. contributor: fullname: Plebanski – year: 2017 ident: bib44 article-title: EGFR-mediated apoptosis via STAT3 publication-title: Exp. Cell Res. contributor: fullname: Ceresa – volume: 10 start-page: 1614 year: 2019 ident: bib34 article-title: Phytochemicals in cancer treatment: from preclinical studies to clinical practice publication-title: Front Pharmacol. contributor: fullname: Prakash – volume: 8 year: 2013 ident: bib52 article-title: Resveratrol induces long-lasting IL-8 expression and peculiar EGFR activation/distribution in human keratinocytes: mechanisms and implications for skin administration publication-title: PLoS One contributor: fullname: Korkina – volume: 14 start-page: 6531 year: 2008 end-page: 6537 ident: bib22 article-title: Cisplatin-resistant neuroblastoma cells express enhanced levels of epidermal growth factor receptor (EGFR) and are sensitive to treatment with EGFR-specific toxins publication-title: Clin. Cancer Res. contributor: fullname: Deubzer – volume: 33 start-page: 3008 year: 2015 end-page: 3017 ident: bib12 article-title: Advances in risk classification and treatment strategies for neuroblastoma publication-title: J. Clin. Oncol. contributor: fullname: Ambros – volume: 5 start-page: 325 year: 2014 ident: bib24 article-title: Molecular recognition of gangliosides and their potential for cancer immunotherapies publication-title: Front Immunol. contributor: fullname: Bousquet – volume: 38 start-page: 1836 year: 2020 end-page: 1848 ident: bib15 article-title: Targets and antibody formats for immunotherapy of neuroblastoma publication-title: J. Clin. Oncol. contributor: fullname: Cheung – volume: 8 start-page: 227 year: 2016 end-page: 241 ident: bib17 article-title: Signaling via the NFκB system publication-title: Wiley Inter. Rev. Syst. Biol. Med. contributor: fullname: Hoffmann – year: 2021 ident: bib37 article-title: The MYC oncogene — the grand orchestrator of cancer growth and immune evasion publication-title: Nat. Rev. Clin. Oncol. contributor: fullname: Felsher – volume: 11 start-page: 681 year: 2004 end-page: 690 ident: bib42 article-title: Inhibition of the NF-κB pathway enhances TRAIL-mediated apoptosis in neuroblastoma cells publication-title: Cancer Gene Ther. contributor: fullname: Bonthius – volume: 11 start-page: 1466 year: 1993 end-page: 1477 ident: bib5 article-title: Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment publication-title: J. Clin. Oncol. contributor: fullname: Castelberry – volume: 404 start-page: 892 year: 2000 end-page: 897 ident: bib19 article-title: Role of NF-κB in p53-mediated programmed cell death publication-title: Nature contributor: fullname: Vousden – volume: 26 year: 2020 ident: bib30 article-title: Ferulic acid induces apoptosis of hela and caski cervical carcinoma cells by down-regulating the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway publication-title: Med Sci. Monit. contributor: fullname: Peng – volume: 123 start-page: 678 year: 2018 end-page: 686 ident: bib53 article-title: Luteolin decreases epidermal growth factor receptor-mediated cell proliferation and induces apoptosis in glioblastoma cell lines publication-title: Basic Clin. Pharmacol. Toxicol. contributor: fullname: Darkwah – volume: 9 start-page: 753 year: 2020 ident: bib26 article-title: Ethnobotany, phytochemistry and pharmacological activity of Kigelia africana (Lam.) Benth. (Bignoniaceae) publication-title: Plants contributor: fullname: Mcgaw – volume: 79 start-page: 629 year: 2016 end-page: 661 ident: bib33 article-title: Natural products as sources of new drugs from 1981 to 2014 publication-title: J. Nat. Prod. contributor: fullname: Cragg – volume: 10 start-page: 89 year: 2018 end-page: 100 ident: bib54 article-title: Mechanism of metastasis suppression by luteolin in breast cancer publication-title: Breast Cancer Targets Ther. contributor: fullname: Cook – volume: 10 start-page: 1000 year: 2020 ident: bib23 article-title: Disialoganglioside GD2 expression in solid tumors and role as a target for cancer therapy publication-title: Front Oncol. contributor: fullname: Owonikoko – volume: 5 year: 2020 ident: bib38 article-title: Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study publication-title: Signal Transduct. Target Ther. contributor: fullname: Hu – volume: 10 start-page: 55 year: 2018 end-page: 61 ident: bib9 article-title: Tolerability, response and outcome of high-risk neuroblastoma patients treated with long-term infusion of anti-GD2 antibody ch14.18/CHO publication-title: mAbs contributor: fullname: Kietz – volume: 27 start-page: 1034 year: 2009 end-page: 1040 ident: bib10 article-title: Excellent outcome with reduced treatment for infants with disseminated neuroblastoma without MYCN gene amplification publication-title: J. Clin. Oncol. contributor: fullname: Di Cataldo – volume: 277 start-page: 42144 year: 2002 end-page: 42150 ident: bib43 article-title: Constitutively active NFkappa B is required for the survival of S-type neuroblastoma publication-title: J. Biol. Chem. contributor: fullname: Castle – volume: 10 start-page: 32 year: 2019 ident: bib27 article-title: Multiple biological effects of an iridoid glucoside, catalpol, and its underlying molecular mechanisms publication-title: Biomolecules contributor: fullname: Choudhury – volume: 358 start-page: 1160 year: 2008 ident: 10.1016/j.biopha.2022.113584_bib20 article-title: EGFR antagonists in cancer treatment publication-title: New Engl. J. Med. doi: 10.1056/NEJMra0707704 contributor: fullname: Ciardiello – volume: 189 start-page: 253 year: 2016 ident: 10.1016/j.biopha.2022.113584_bib35 article-title: Kigelia africana (Lam.) Benth. (Sausage tree): phytochemistry and pharmacological review of a quintessential African traditional medicinal plant publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2016.05.049 contributor: fullname: Bello – volume: 10 start-page: 502 year: 2020 ident: 10.1016/j.biopha.2022.113584_bib49 article-title: Luteolin-7-O-glucoside inhibits oral cancer cell migration and invasion by regulating matrix metalloproteinase-2 expression and extracellular signal-regulated kinase pathway publication-title: Biomolecules doi: 10.3390/biom10040502 contributor: fullname: Velmurugan – year: 2017 ident: 10.1016/j.biopha.2022.113584_bib44 article-title: EGFR-mediated apoptosis via STAT3 publication-title: Exp. Cell Res. doi: 10.1016/j.yexcr.2017.04.016 contributor: fullname: Jackson – volume: 177 start-page: 3009 year: 2020 ident: 10.1016/j.biopha.2022.113584_bib51 article-title: A low MW inhibitor of CD44 dimerization for the treatment of glioblastoma publication-title: Br. J. Pharm. doi: 10.1111/bph.15030 contributor: fullname: Wang – year: 2021 ident: 10.1016/j.biopha.2022.113584_bib37 article-title: The MYC oncogene — the grand orchestrator of cancer growth and immune evasion publication-title: Nat. Rev. Clin. Oncol. contributor: fullname: Dhanasekaran – volume: 10 year: 2020 ident: 10.1016/j.biopha.2022.113584_bib11 article-title: MYCN function in neuroblastoma development publication-title: Front Oncol. contributor: fullname: Otte – volume: 38 start-page: 1836 year: 2020 ident: 10.1016/j.biopha.2022.113584_bib15 article-title: Targets and antibody formats for immunotherapy of neuroblastoma publication-title: J. Clin. Oncol. doi: 10.1200/JCO.19.01410 contributor: fullname: Park – volume: 11 year: 2021 ident: 10.1016/j.biopha.2022.113584_bib48 article-title: Tumor-induced inflammatory cytokines and the emerging diagnostic devices for cancer detection and prognosis publication-title: Front Oncol. doi: 10.3389/fonc.2021.692142 contributor: fullname: Kartikasari – volume: 7 year: 2017 ident: 10.1016/j.biopha.2022.113584_bib50 article-title: The lichen secondary metabolite atranorin suppresses lung cancer cell motility and tumorigenesis publication-title: Sci. Rep. contributor: fullname: Zhou – volume: 8 start-page: 634 year: 2008 ident: 10.1016/j.biopha.2022.113584_bib29 article-title: Luteolin a flavonoid with potential for cancer prevention and therapy publication-title: Curr. Cancer Drug Targets doi: 10.2174/156800908786241050 contributor: fullname: Lin – volume: 10 year: 2020 ident: 10.1016/j.biopha.2022.113584_bib32 article-title: Verminoside from Pseudolysimachion rotundum var. subintegrum sensitizes cisplatin-resistant cancer cells and suppresses metastatic growth of human breast cancer publication-title: Sci. Rep. contributor: fullname: Lee – volume: 49 start-page: 82 year: 2019 ident: 10.1016/j.biopha.2022.113584_bib16 article-title: CD44-high neural crest stem-like cells are associated with tumour aggressiveness and poor survival in neuroblastoma tumours publication-title: EBioMedicine doi: 10.1016/j.ebiom.2019.10.041 contributor: fullname: Vega – volume: 13 start-page: 563 year: 2013 ident: 10.1016/j.biopha.2022.113584_bib14 article-title: Cell survival signaling in neuroblastoma publication-title: Anti Cancer Agents Med Chem. doi: 10.2174/1871520611313040005 contributor: fullname: Megison – volume: 14 start-page: 6531 year: 2008 ident: 10.1016/j.biopha.2022.113584_bib22 article-title: Cisplatin-resistant neuroblastoma cells express enhanced levels of epidermal growth factor receptor (EGFR) and are sensitive to treatment with EGFR-specific toxins publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-08-0821 contributor: fullname: Michaelis – volume: 5 start-page: 325 year: 2014 ident: 10.1016/j.biopha.2022.113584_bib24 article-title: Molecular recognition of gangliosides and their potential for cancer immunotherapies publication-title: Front Immunol. doi: 10.3389/fimmu.2014.00325 contributor: fullname: Krengel – volume: 8 year: 2013 ident: 10.1016/j.biopha.2022.113584_bib52 article-title: Resveratrol induces long-lasting IL-8 expression and peculiar EGFR activation/distribution in human keratinocytes: mechanisms and implications for skin administration publication-title: PLoS One doi: 10.1371/journal.pone.0059632 contributor: fullname: Pastore – volume: 21 start-page: 401 year: 2020 ident: 10.1016/j.biopha.2022.113584_bib31 article-title: Alleviation of multidrug resistance by flavonoid and non-flavonoid compounds in breast, lung, colorectal and prostate cancer publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms21020401 contributor: fullname: Costea – volume: 11 start-page: 681 year: 2004 ident: 10.1016/j.biopha.2022.113584_bib42 article-title: Inhibition of the NF-κB pathway enhances TRAIL-mediated apoptosis in neuroblastoma cells publication-title: Cancer Gene Ther. doi: 10.1038/sj.cgt.7700749 contributor: fullname: Karacay – volume: 369 start-page: 2106 year: 2007 ident: 10.1016/j.biopha.2022.113584_bib2 article-title: Neuroblastoma publication-title: Lancet doi: 10.1016/S0140-6736(07)60983-0 contributor: fullname: Maris – volume: 79 start-page: 629 year: 2016 ident: 10.1016/j.biopha.2022.113584_bib33 article-title: Natural products as sources of new drugs from 1981 to 2014 publication-title: J. Nat. Prod. doi: 10.1021/acs.jnatprod.5b01055 contributor: fullname: Newman – volume: 5 year: 2020 ident: 10.1016/j.biopha.2022.113584_bib38 article-title: Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study publication-title: Signal Transduct. Target Ther. contributor: fullname: Yu – volume: 267 start-page: 3828 year: 2000 ident: 10.1016/j.biopha.2022.113584_bib41 article-title: The pro- or anti-apoptotic function of NF-κB is determined by the nature of the apoptotic stimulus publication-title: Eur. J. Biochem. doi: 10.1046/j.1432-1327.2000.01421.x contributor: fullname: Kaltschmidt – volume: 27 start-page: 1034 year: 2009 ident: 10.1016/j.biopha.2022.113584_bib10 article-title: Excellent outcome with reduced treatment for infants with disseminated neuroblastoma without MYCN gene amplification publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2008.17.5877 contributor: fullname: De Bernardi – volume: 2 start-page: 16078 year: 2016 ident: 10.1016/j.biopha.2022.113584_bib3 article-title: Neuroblastoma publication-title: Nat. Rev. Dis. Prim. doi: 10.1038/nrdp.2016.78 contributor: fullname: Matthay – volume: 26 start-page: 6452 year: 2021 ident: 10.1016/j.biopha.2022.113584_bib55 article-title: Luteolin inhibits breast cancer stemness and enhances chemosensitivity through the Nrf2-mediated pathway publication-title: Molecules doi: 10.3390/molecules26216452 contributor: fullname: Tsai – volume: 404 start-page: 892 year: 2000 ident: 10.1016/j.biopha.2022.113584_bib19 article-title: Role of NF-κB in p53-mediated programmed cell death publication-title: Nature doi: 10.1038/35009130 contributor: fullname: Ryan – volume: 10 year: 2015 ident: 10.1016/j.biopha.2022.113584_bib40 article-title: NF-κB regulates caspase-4 expression and sensitizes neuroblastoma cells to fas-induced apoptosis publication-title: PLoS One contributor: fullname: Yang – volume: 27 start-page: 298 year: 2009 ident: 10.1016/j.biopha.2022.113584_bib6 article-title: The International neuroblastoma risk group (INRG) staging system: an INRG task force report publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2008.16.6876 contributor: fullname: Monclair – volume: 9 start-page: 78 year: 2021 ident: 10.1016/j.biopha.2022.113584_bib8 article-title: MYCN in Neuroblastoma: “Old Wine into New Wineskins” publication-title: Diseases doi: 10.3390/diseases9040078 contributor: fullname: Braoudaki – volume: 10 start-page: 89 year: 2018 ident: 10.1016/j.biopha.2022.113584_bib54 article-title: Mechanism of metastasis suppression by luteolin in breast cancer publication-title: Breast Cancer Targets Ther. doi: 10.2147/BCTT.S144202 contributor: fullname: Cook – volume: 261 start-page: 243 year: 2011 ident: 10.1016/j.biopha.2022.113584_bib4 article-title: Guidelines for imaging and staging of neuroblastic tumors: consensus report from the international neuroblastoma risk group project publication-title: Radiology doi: 10.1148/radiol.11101352 contributor: fullname: Brisse – volume: 48 start-page: 762 year: 2016 ident: 10.1016/j.biopha.2022.113584_bib21 article-title: Epidermal growth factor receptor is overexpressed in neuroblastoma tissues and cells publication-title: Acta Biochim Biophys. Sin. doi: 10.1093/abbs/gmw064 contributor: fullname: Zheng – volume: 65 start-page: 9868 year: 2005 ident: 10.1016/j.biopha.2022.113584_bib13 article-title: Proliferation of human neuroblastomas mediated by the epidermal growth factor receptor publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-04-2426 contributor: fullname: Ho – volume: 123 start-page: 678 year: 2018 ident: 10.1016/j.biopha.2022.113584_bib53 article-title: Luteolin decreases epidermal growth factor receptor-mediated cell proliferation and induces apoptosis in glioblastoma cell lines publication-title: Basic Clin. Pharmacol. Toxicol. doi: 10.1111/bcpt.13077 contributor: fullname: Anson – volume: 33 start-page: 3008 year: 2015 ident: 10.1016/j.biopha.2022.113584_bib12 article-title: Advances in risk classification and treatment strategies for neuroblastoma publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2014.59.4648 contributor: fullname: Pinto – volume: 277 start-page: 42144 year: 2002 ident: 10.1016/j.biopha.2022.113584_bib43 article-title: Constitutively active NFkappa B is required for the survival of S-type neuroblastoma publication-title: J. Biol. Chem. doi: 10.1074/jbc.M203891200 contributor: fullname: Bian – volume: 10 start-page: 1000 year: 2020 ident: 10.1016/j.biopha.2022.113584_bib23 article-title: Disialoganglioside GD2 expression in solid tumors and role as a target for cancer therapy publication-title: Front Oncol. doi: 10.3389/fonc.2020.01000 contributor: fullname: Nazha – volume: 112 year: 2019 ident: 10.1016/j.biopha.2022.113584_bib36 article-title: Luteolin, a flavonoid, as an anticancer agent: a review publication-title: Biomed. Pharm. doi: 10.1016/j.biopha.2019.108612 contributor: fullname: Imran – volume: 10 start-page: 32 year: 2019 ident: 10.1016/j.biopha.2022.113584_bib27 article-title: Multiple biological effects of an iridoid glucoside, catalpol, and its underlying molecular mechanisms publication-title: Biomolecules doi: 10.3390/biom10010032 contributor: fullname: Bhattamisra – volume: 441 start-page: 431 year: 2006 ident: 10.1016/j.biopha.2022.113584_bib18 article-title: Nuclear factor-κB in cancer development and progression publication-title: Nature doi: 10.1038/nature04870 contributor: fullname: Karin – volume: 24 start-page: 2901 year: 2020 ident: 10.1016/j.biopha.2022.113584_bib28 article-title: Verbascoside inhibits progression of glioblastoma cells by promoting Let-7g-5p and down-regulating HMGA2 via Wnt/beta-catenin signalling blockade publication-title: J. Cell Mol. Med. doi: 10.1111/jcmm.14884 contributor: fullname: Jia – volume: 8 start-page: 227 year: 2016 ident: 10.1016/j.biopha.2022.113584_bib17 article-title: Signaling via the NFκB system publication-title: Wiley Inter. Rev. Syst. Biol. Med. doi: 10.1002/wsbm.1331 contributor: fullname: Mitchell – volume: 19 start-page: 349 year: 2015 ident: 10.1016/j.biopha.2022.113584_bib25 article-title: Disialoganglioside GD2 as a therapeutic target for human diseases publication-title: Expert Opin. Ther. Targets doi: 10.1517/14728222.2014.986459 contributor: fullname: Suzuki – volume: 10 start-page: 1614 year: 2019 ident: 10.1016/j.biopha.2022.113584_bib34 article-title: Phytochemicals in cancer treatment: from preclinical studies to clinical practice publication-title: Front Pharmacol. doi: 10.3389/fphar.2019.01614 contributor: fullname: Choudhari – volume: 9 start-page: 753 year: 2020 ident: 10.1016/j.biopha.2022.113584_bib26 article-title: Ethnobotany, phytochemistry and pharmacological activity of Kigelia africana (Lam.) Benth. (Bignoniaceae) publication-title: Plants doi: 10.3390/plants9060753 contributor: fullname: Nabatanzi – volume: 26 year: 2020 ident: 10.1016/j.biopha.2022.113584_bib30 article-title: Ferulic acid induces apoptosis of hela and caski cervical carcinoma cells by down-regulating the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway publication-title: Med Sci. Monit. doi: 10.12659/MSM.920095 contributor: fullname: Luo – volume: 229 start-page: 147 year: 2017 ident: 10.1016/j.biopha.2022.113584_bib7 article-title: GPOH guidelines for diagnosis and treatment of patients with neuroblastic tumors publication-title: Klin. Padiatr. doi: 10.1055/s-0043-103086 contributor: fullname: Simon – volume: 108 start-page: 370 year: 2013 ident: 10.1016/j.biopha.2022.113584_bib47 article-title: Nuclear EGFR as a molecular target in cancer publication-title: Radio. Oncol. doi: 10.1016/j.radonc.2013.06.010 contributor: fullname: Brand – volume: 95 start-page: 211 year: 2006 ident: 10.1016/j.biopha.2022.113584_bib46 article-title: EGFR signaling pathway in breast cancers: from traditional signal transduction to direct nuclear translocalization publication-title: Breast Cancer Res Treat. doi: 10.1007/s10549-005-9011-0 contributor: fullname: Lo – volume: 11 start-page: 1466 year: 1993 ident: 10.1016/j.biopha.2022.113584_bib5 article-title: Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment publication-title: J. Clin. Oncol. doi: 10.1200/JCO.1993.11.8.1466 contributor: fullname: Brodeur – volume: 52 start-page: 538 year: 1992 ident: 10.1016/j.biopha.2022.113584_bib1 article-title: International variations in the incidence of neuroblastoma publication-title: Int. J. Cancer doi: 10.1002/ijc.2910520407 contributor: fullname: Stiller – volume: 94 start-page: 184 year: 2006 ident: 10.1016/j.biopha.2022.113584_bib45 article-title: Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival publication-title: Br. J. Cancer doi: 10.1038/sj.bjc.6602941 contributor: fullname: Lo – volume: 10 start-page: 55 year: 2018 ident: 10.1016/j.biopha.2022.113584_bib9 article-title: Tolerability, response and outcome of high-risk neuroblastoma patients treated with long-term infusion of anti-GD2 antibody ch14.18/CHO publication-title: mAbs doi: 10.1080/19420862.2017.1402997 contributor: fullname: Mueller – volume: 35 start-page: 349 year: 2015 ident: 10.1016/j.biopha.2022.113584_bib39 article-title: Involvement of the nuclear factor-κB signaling pathway in the regulation of CXC chemokine receptor-4 expression in neuroblastoma cells induced by tumor necrosis factor-α publication-title: Int. J. Mol. Med. doi: 10.3892/ijmm.2014.2032 contributor: fullname: Zhi |
SSID | ssj0005638 |
Score | 2.4052913 |
Snippet | Neuroblastoma (NB) is one of the most common solid pediatric tumors and especially high-risk NBs still account for about 12–15% of cancer related deaths in... |
SourceID | doaj proquest crossref elsevier |
SourceType | Open Website Aggregation Database Publisher |
StartPage | 113584 |
SubjectTerms | Cancer EGFR Kigelia africana Neuroblastoma NF-κB Phytotherapeutics |
SummonAdditionalLinks | – databaseName: ScienceDirect Freedom Collection 2013 dbid: .~1 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELaqHiouCAqI8pKRUE8Nm40fcY5QtapARZVopd6s8WsJKsmqSQ-98NsZ20nb5YLEMc7IsTyTedgz3xDygQMvrQysKEMjC24wTmlEaQuwgnvZMKdMDBRPv8mTC_7lUlxukcO5FiamVU66P-v0pK2nkcW0m4t12y6-o7FjLF4UVAlzJhb8cjRGKNMffz9I85Cpm3UkLiL1XD6XcrxM20dQpgoNWWxuIhTfME8JxX_DSv2lr5MROn5CHk_eI_2UF_iUbPlul-ycTvfju2T_LCNR3x7Q8_vCquGA7tOze4zq22fEfG1X_qoFCqlPUAe07X60ph0Huo59fILPkkGhc_jKoQAMNB7yUxd9Rhyi6FauPOU0wXsYdMLH_hdkmui6Ds_JxfHR-eFJMbVbKCwXy7EAV7JghYHgnTBecGNQzEJQtuHSKKe4hYDuJF86JhpXc4yU0PzVUBpkaOnYC7Ld9Z1_SahXCcUHhAqSo4doHIZlbllbDoYF0eyRYt5lvc6oGnpON_upM1d05IrOXNkjnyMr7mgjJnYa6K9XehIKbcEvTVNJ4Aq4ayolbIlrloBKyymGk9QzI_WGiOFU7T8-_37mu8a_L-4kdL6_GXRVx3MgDMmqV_89-2vyKD7lDME3ZHu8vvFv0dMZzbskyn8AdaD8Nw priority: 102 providerName: Elsevier |
Title | Kigelia africana inhibits proliferation and induces cell death in stage 4 Neuroblastoma cell lines |
URI | https://dx.doi.org/10.1016/j.biopha.2022.113584 https://search.proquest.com/docview/2707617472 https://doaj.org/article/cae1b926a48a4d9285c084c6a832d834 |
Volume | 154 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Nb9QwELWgSIgLggJiga6MhHpqIIntxDmWimqh6tJDK624WOOvNgiyFUkPvfDbGdtJvy69cIxjxZbnJfPGGb8h5AMHnpvKsyz3TZVxjXFKI3KTgRHcVQ2zUodA8XBZLU74t5VY3Sj1FXLCkjxwWrhPBlyhm7ICLoHbppTC5JKbChCKVrKkBFqIKZiakjuqWMMa_SHLGGJ2OjQXM7t0uw5STBj2l6GkiZD8llOK2v23fNOdr3R0PfvPyNORM9LdNNfn5IHrNsnjw_Gv-CbZPkr605c79Pj6OFW_Q7fp0bUy9eULog_aU_erBQqxOlAHtO3OWt0OPT0P1Xu8S3ig0Fm8ZdHsPQ1b-9QGpohNFMnkqaOcRlEPjdR7WP-G1CcQ1v4lOdn_cry3yMYiC5nhohgysDnzRmjwzgrtBNcaweW9NA2vtLS41uCRRPLCMtHYmmN8hE6vhlyjGXPLXpGNbt2514Q6GbV7QEhfceSF2mIwZovacNDMi2ZGsmmV1XnS0lBTktlPlayiglVUssqMfA6muOoblLBjA-JDjfhQ9-FjRurJkGokFYks4KPae4Z_P9ld4TsXVhI6t77oVVmH3R8MxMo3_2OKb8mTMGxKEXxHNoY_F24Lqc6g5-Thx7_FnDza_XqwWM4jxvFqubf6_uMfA0P_Ow |
link.rule.ids | 315,786,790,870,2115,4521,24144,27957,27958,45620,45714 |
linkProvider | Directory of Open Access Journals |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9QwELVKkaAXBAVEoYCRUE8Nm03sxDlCRbXQblWJrdSb5c8lVZusmvTQC7-9M3ZCWS5IXG3LsTyTmTf2-A0hH5liqSl8nqS-KhKmIU6peGoSZThzRZVboTFQnJ8UszP2_Zyfb5CD8S0MplUOtj_a9GCth5bJsJuTVV1PfoCzy3O8KMgC54x4QB4inMf6DZ9-_ZHnUYRy1jg6weHj-7mQ5KXrFlmZMvBkWN2EC7bmnwKN_5qb-stgBy90-JQ8GeAj_RxX-IxsuGabPJoPF-TbZO80UlHf7tPF_cuqbp_u0dN7kurb50Qf1Ut3WSuqQqGgRtG6-Vnruu_oCgv5eBdVg6rGQpcFDegonvJTi6ARmijgyqWjjAZ-Dw0ovG-vVByD2LV7Qc4Ovy4OZslQbyExjE_7RNk094Zr5Z3l2nGmNeiZ98JUrNDCCmaUBzzJpjbnlS0ZhErg_0qVapBoavOXZLNpG_eKUCcCjY_iwhcMIKK2EJfZaWmY0rnn1Q5Jxl2Wq0irIcd8swsZpSJRKjJKZYd8QVH8Houk2KGhvV7KQSukUW6qq6xQTChmq0xwk8KaCwVWy4ocJilHQco1HYOp6n98_sModwm_H-6kalx708msxIMgiMmy1_89-3vyeLaYH8vjbydHb8gW9sR0wV2y2V_fuLcAe3r9Lqj1HSjM_1c |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Kigelia+africana+inhibits+proliferation+and+induces+cell+death+in+stage+4+Neuroblastoma+cell+lines&rft.jtitle=Biomedicine+%26+pharmacotherapy&rft.au=Sofia+Ahrens&rft.au=Birgit+Appl&rft.au=Magdalena+Trochimiuk&rft.au=Charlotte+D%C3%BCcker&rft.date=2022-10-01&rft.pub=Elsevier&rft.issn=0753-3322&rft.eissn=1950-6007&rft.volume=154&rft.spage=113584&rft_id=info:doi/10.1016%2Fj.biopha.2022.113584&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_cae1b926a48a4d9285c084c6a832d834 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0753-3322&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0753-3322&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0753-3322&client=summon |