Macrophage subpopulations and macrophage-derived cytokines in sputum of atopic and nonatopic asthmatic subjects and atopic and normal control subjects

• Published in: Journal of allergy and clinical immunology Vol. 106; no. 4; pp. 697 - 704
• Main Authors: Zeibecoglou, Kyriaki, Ying, Sun, Meng, Qiu, Poulter, Leonard W., Robinson, Douglas S., Kay, A.Barry
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.10.2000; Elsevier
• Subjects: Allergic diseases; Asthma; Asthma - pathology; atopy; Biological and medical sciences; Cell Count; Chronic obstructive pulmonary disease, asthma; Cytokines - metabolism; Epithelial Cells - metabolism; Humans; Hypersensitivity, Immediate - pathology; IL-10; IL-12; Immunopathology; Interleukin-10 - biosynthesis; Interleukin-10 - genetics; Interleukin-12 - biosynthesis; Interleukin-12 - genetics; macrophage; Macrophages - classification; Medical sciences; Multicenter Studies as Topic; Pneumology; Respiratory and ent allergic diseases; Respiratory Function Tests; RNA, Messenger - metabolism; Sputum - chemistry; Sputum - cytology; AA; AC; NC; atopy; macrophage; IL-12; IL-10; Asthma; NAA; Intrinsic asthma; Human; Allergy; Immunopathology; Pathophysiology; Respiratory disease; Cytokine; Interleukin 12; Inflammation; Atopy; Respiratory tract; Sputum; Interleukin 10; Obstructive pulmonary disease; Comparative study; Macrophage

Background: Previous studies have shown a prominent macrophage signal in the bronchial mucosa from nonatopic (intrinsic) compared with atopic (extrinsic) asthmatic subjects. This observation might have represented an expansion of a proinflammatory macrophage population or a homeostatic mechanism to...