The Landscape and Therapeutic Targeting of BRCA1, BRCA2 and Other DNA Damage Response Genes in Pancreatic Cancer

• Published in: Current issues in molecular biology Vol. 45; no. 3; pp. 2105 - 2120
• Main Authors: Voutsadakis, Ioannis A., Digklia, Antonia
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 03.03.2023; MDPI AG
• Subjects: ATR inhibitors; DNA damage response; homologous recombination; pancreatic adenocarcinoma; PARP; Review; pancreatic adenocarcinoma; PARP; homologous recombination; DNA damage response; ATR inhibitors

Genes participating in the cellular response to damaged DNA have an important function to protect genetic information from alterations due to extrinsic and intrinsic cellular insults. In cancer cells, alterations in these genes are a source of genetic instability, which is advantageous for cancer pr...