Protective effect of autophagy in neural ischemia and hypoxia: Negative regulation of the Wnt/β-catenin pathway

• Published in: International journal of molecular medicine Vol. 40; no. 6; pp. 1699 - 1708
• Main Authors: Shi, Zhen-Yu, Deng, Jie-Xin, Fu, Su, Wang, Lai, Wang, Qiang, Liu, Bin, Li, Yong-Qiang, Deng, Jin-Bo
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.12.2017; Spandidos Publications UK Ltd
• Subjects: Autophagy; Cell culture; Cell growth; Glucose; Hypoxia; inflammation; ischemic and hypoxic injuries; oxygen and glucose deprivation; Proteins; Studies; Wnt signaling

Autophagy is a highly conserved process of self-digestion to promote cell survival in response to nutrient starvation and other metabolic stresses. However, whether ischemic-hypoxic (IH) injury-induced autophagy acts as a neuroprotective mechanism or leads to neuroinjury is a subject of debate. It i...