Re-thinking the possible interaction between proton pump inhibitors and capecitabine

• Published in: Cancer chemotherapy and pharmacology Vol. 90; no. 5; pp. 381 - 388
• Main Authors: Jeong, Soo Hee, Molloy, Lara, Ang, Edmond, Helsby, Nuala
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2022; Springer Nature B.V
• Subjects: Bioavailability; Cancer Research; Cancer therapies; Chemotherapy; Colorectal cancer; Drug dosages; Drug interactions; Gastritis; Gastroesophageal reflux; Inhibitors; Long-term effects; Medicine; Medicine & Public Health; Observational studies; Oncology; Patients; Pharmacokinetics; Pharmacology; Pharmacology/Toxicology; Proton pump inhibitors; Review; Review Article; Treatment outcomes; Proton pump inhibitors; Capecitabine; Drug–drug interaction

Proton Pump Inhibitors (PPI) rank within the top ten most prescribed medications in Europe and USA. A high frequency of PPI use has been reported amongst patients undergoing chemotherapy, to mitigate treatment-induced gastritis or gastro-oesophageal reflux. Several recent, mostly retrospective, obse...