Daily intake of heat-killed Lactobacillus plantarum L-137 enhances type I interferon production in healthy humans and pigs

• Published in: Immunopharmacology and immunotoxicology Vol. 34; no. 6; pp. 937 - 943
• Main Authors: Arimori, Yojiro, Nakamura, Risa, Hirose, Yoshitaka, Murosaki, Shinji, Yamamoto, Yoshihiro, Shidara, Osamu, Ichikawa, Hiroshi, Yoshikai, Yasunobu
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.12.2012; Taylor & Francis
• Subjects: Adult; Animals; Female; human; Humans; Influenza A virus; Influenza A virus - immunology; Influenza Vaccines - administration & dosage; Influenza Vaccines - immunology; Interferon Inducers - administration & dosage; Interferon Inducers - immunology; Interferon-beta - immunology; interferon-β; Lactobacillus plantarum; Lactobacillus plantarum L-137; Mice; Middle Aged; Orthomyxoviridae Infections - immunology; Orthomyxoviridae Infections - prevention & control; pig; Swine; type I interferon; Vaccination

We have previously reported that oral administration of heat-killed Lactobacillus plantarum L-137 (HK L-137) stimulates innate immunity for production of type I interferon (IFN) which subsequently augments host defense against influenza A virus infection in mice. We here examined the effect of HK L-...