Co-exposure to polystyrene microplastics and lead aggravated ovarian toxicity in female mice via the PERK/eIF2α signaling pathway

• Published in: Ecotoxicology and environmental safety Vol. 243; p. 113966
• Main Authors: Feng, Yueying, Yuan, Hongbin, Wang, Wanzhen, Xu, Yuanyuan, Zhang, Jinfeng, Xu, Hengyi, Fu, Fen
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 15.09.2022; Elsevier
• Subjects: Combined exposure; Ovarian toxicity; Oxidative stress; PERK/eIF2α signaling pathway; PS-MPs; Bcl-2; Oxidative stress; IHC; PERK; MDA; PS-MPs; E2; HMs; P; Pb; EDS; UPR; FTIR; Ovarian toxicity; CHOP; RT-qPCR; IF; Combined exposure; H&E; Bip; SOD; ER; eIF2α; NAC; PERK/eIF2α signaling pathway; Bax; SEM; Sal; ATF4

Generally, individual microplastics (MPs) or lead (Pb) exposure could initiate ovarian toxicity. However, their combined effects on the ovary and its mechanism in mammals remained unclear. Female C57BL/6 mice were used in this study to investigate the combined ovarian toxicity of polystyrene MPs (PS...