Lower viral loads in subjects with rhinovirus-challenged allergy despite reduced innate immunity

• Published in: Annals of allergy, asthma, & immunology Vol. 128; no. 4; pp. 414 - 422.e2
• Main Authors: Feng, Xin, Lawrence, Monica G., Payne, Spencer C., Mattos, Jose, Etter, Elaine, Negri, Julie A., Murphy, Deborah, Kennedy, Joshua L., Steinke, John W., Borish, Larry
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2022
• Subjects: Asthma; Humans; Immunity, Innate; Picornaviridae Infections; Rhinitis, Allergic - complications; Rhinovirus; Viral Load

Viral infections, especially those caused by rhinovirus, are the most common cause of asthma exacerbations. Previous studies have argued that impaired innate antiviral immunity and, as a consequence, more severe infections contribute to these exacerbations. These studies explored the innate immune r...